Design and Synthesis of Tesirine, a Clinical Antibody–Drug Conjugate Pyrrolobenzodiazepine Dimer Payload

por Tiberghien, Arnaud C., Levy, Jean-Noel, Masterson, Luke A., Patel, Neki V., Adams, Lauren R., Corbett, Simon, Williams, David G., Hartley, John A., Howard, Philip W.
Publicado en ACS Med Chem Lett (2016)

SG2285, a novel C2-aryl-substituted pyrrolobenzodiazepine dimer pro-drug that cross-links DNA and exerts highly potent antitumor activity

por Hartley, John A., Hamaguchi, Anzu, Coffils, Marissa, Martin, Christopher R.H., Suggitt, Marie, Chen, Zhizhi, Gregson, Stephen J., Masterson, Luke A., Tiberghien, Arnaud C., Hartley, Janet M., Pepper, Christopher, Lin, Thet Thet, Fegan, Christopher, Thurston, David E., Howard, Philip W.
Publicado 2010

Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine

por Hartley, John A., Flynn, Michael J., Bingham, John P., Corbett, Simon, Reinert, Halla, Tiberghien, Arnaud, Masterson, Luke A., Antonow, Dyeison, Adams, Lauren, Chowdhury, Sajidah, Williams, David G., Mao, Shenlan, Harper, Jay, Havenith, Carin E. G., Zammarchi, Francesca, Chivers, Simon, van Berkel, Patrick H., Howard, Philip W.
Publicado en Sci Rep (2018)