Protein Phosphatase-1 –targeted Small Molecules, Iron Chelators and Curcumin Analogs as HIV-1 Antivirals

per Lin, Xionghao, Ammosova, Tatyana, Kumari, Namita, Nekhai, Sergei
Publicat a Curr Pharm Des (2017)

Discovery of a Novel HDAC2 Inhibitor by a Scaffold-Merging Hybrid Query

per Basant, Nikita, Lin, Xionghao, Reid, Terry-Elinor R., Karla, Pradeep K., Wang, Xiang S.
Publicat a Comb Chem High Throughput Screen (2015)

Urinary Orosomucoid is Associated with Progressive Chronic Kidney Disease Stage in Patients with Sickle Cell Anemia

per Jerebtsova, Marina, Saraf, Santosh L., Soni, Simran, Afangbedji, Nowah, Lin, Xionghao, Raslan, Rasha, Gordeuk, Victor R., Nekhai, Sergei
Publicat a Am J Hematol (2018)

Protein Phosphatase 1α Interacts with Venezuelan Equine Encephalitis Virus Capsid Protein and Regulates Viral Replication through Modulation of Capsid Phosphorylation

per Carey, Brian D., Ammosova, Tatiana, Pinkham, Chelsea, Lin, Xionghao, Zhou, Weidong, Liotta, Lance A., Nekhai, Sergei, Kehn-Hall, Kylene
Publicat a J Virol (2018)

Inhibition of HIV-1 by curcumin A, a novel curcumin analog

per Kumari, Namita, Kulkarni, Amol A, Lin, Xionghao, McLean, Charlee, Ammosova, Tatiana, Ivanov, Andrey, Hipolito, Maria, Nekhai, Sergei, Nwulia, Evaristus
Publicat a Drug Des Devel Ther (2015)

Increased iron export by ferroportin induces restriction of HIV-1 infection in sickle cell disease

per Kumari, Namita, Ammosova, Tatiana, Diaz, Sharmin, Lin, Xionghao, Niu, Xiaomei, Ivanov, Andrey, Jerebtsova, Marina, Dhawan, Subhash, Oneal, Patricia, Nekhai, Sergei
Publicat a Blood Adv (2016)

Phosphorylated VP30 of Marburg Virus Is a Repressor of Transcription

per Tigabu, Bersabeh, Ramanathan, Palaniappan, Ivanov, Andrey, Lin, Xionghao, Ilinykh, Philipp A., Parry, Christian S., Freiberg, Alexander N., Nekhai, Sergei, Bukreyev, Alexander
Publicat a J Virol (2018)

Phenyl-1-Pyridin-2yl-Ethanone-Based Iron Chelators Increase IκB-α Expression, Modulate CDK2 and CDK9 Activities, and Inhibit HIV-1 Transcription

per Kumari, Namita, Iordanskiy, Sergey, Kovalskyy, Dmytro, Breuer, Denitra, Niu, Xiaomei, Lin, Xionghao, Xu, Min, Gavrilenko, Konstantin, Kashanchi, Fatah, Dhawan, Subhash, Nekhai, Sergei
Publicat a Antimicrob Agents Chemother (2014)

HIV-1 Tat phosphorylation on Ser-16 residue modulates HIV-1 transcription

per Ivanov, Andrey, Lin, Xionghao, Ammosova, Tatiana, Ilatovskiy, Andrey V., Kumari, Namita, Lassiter, Hatajai, Afangbedji, Nowah, Niu, Xiaomei, Petukhov, Michael G., Nekhai, Sergei
Publicat a Retrovirology (2018)

Protein Phosphatase 1 Regulates Human Cytomegalovirus Protein Translation by Restraining AMPK Signaling

per Stecher, Carmen, Marinkov, Sanja, Mayr-Harting, Lucia, Katic, Ana, Kastner, Marie-Theres, Rieder-Rommer, Franz J. J., Lin, Xionghao, Nekhai, Sergei, Steininger, Christoph
Publicat a Front Microbiol (2021)

Activation of HIV-1 with Nanoparticle-Packaged Small-Molecule Protein Phosphatase-1-Targeting Compound

per Smith, Kahli A., Lin, Xionghao, Bolshakov, Oleg, Griffin, James, Niu, Xiaomei, Kovalskyy, Dmytro, Ivanov, Andrey, Jerebtsova, Marina, Taylor, Robert E., Akala, Emmanuel, Nekhai, Sergei
Publicat a Sci Pharm (2015)

Global phosphoproteomic analysis of Ebola virions reveals a novel role for VP35 phosphorylation-dependent regulation of genome transcription

per Ivanov, Andrey, Ramanathan, Palaniappan, Parry, Christian, Ilinykh, Philipp A., Lin, Xionghao, Petukhov, Michael, Obukhov, Yuri, Ammosova, Tatiana, Amarasinghe, Gaya K., Bukreyev, Alexander, Nekhai, Sergei
Publicat a Cell Mol Life Sci (2019)

Identification of ceruloplasmin as a biomarker of chronic kidney disease in urine of sickle cell disease patients by proteomic analysis

per Jerebtsova, Marina, Saraf, Santosh L., Lin, Xionghao, Lee, Gillian, Adjei, Elena Afia, Kumari, Namita, Afangbedji, Nowah, Raslan, Rasha, McLean, Charlee, Gordeuk, Victor R., Nekhai, Sergei
Publicat a Am J Hematol (2017)

Protein Phosphatase 1–Targeting Small-Molecule C31 Inhibits Ebola Virus Replication

per Ammosova, Tatiana, Pietzsch, Colette A, Saygideğer, Yasemin, Ilatovsky, Andrey, Lin, Xionghao, Ivanov, Andrey, Kumari, Namita, Jerebtsova, Marina, Kulkarni, Amol, Petukhov, Michael, Üren, Aykut, Bukreyev, Alexander, Nekhai, Sergei
Publicat a J Infect Dis (2018)

Targeting the Non-catalytic RVxF Site of Protein Phosphatase-1 With Small Molecules for Ebola Virus Inhibition

per Lin, Xionghao, Ammosova, Tatiana, Choy, Meng S., Pietzsch, Colette A., Ivanov, Andrey, Ahmad, Asrar, Saygideğer, Yasemin, Kumari, Namita, Kovalskyy, Dmytro, Üren, Aykut, Peti, Wolfgang, Bukreyev, Alexander, Nekhai, Sergei
Publicat a Front Microbiol (2019)

Structural Optimization of 2,3-Dihydro-1H-cyclopenta[b]quinolines Targeting the Noncatalytic RVxF Site of Protein Phosphatase 1 for HIV-1 Inhibition

per Lin, Xionghao, Sajith, Ayyiliath M, Wang, Songping, Kumari, Namita, Choy, Meng S, Ahmad, Asrar, Cadet, Dana R., Gu, Xinbin, Ivanov, Andrey I., Peti, Wolfgang, Kulkarni, Amol, Nekhai, Sergei
Publicat a ACS Infect Dis (2020)

Inhibition of HIV-1 infection in humanized mice and metabolic stability of protein phosphatase-1-targeting small molecule 1E7-03

per Lin, Xionghao, Kumari, Namita, DeMarino, Catherine, Kont, Yasemin Saygideğer, Ammosova, Tatiana, Kulkarni, Amol, Jerebtsova, Marina, Vazquez-Meves, Guelaguetza, Ivanov, Andrey, Dmytro, Kovalskyy, Üren, Aykut, Kashanchi, Fatah, Nekhai, Sergei
Publicat a Oncotarget (2017)