Can Systems Biology Understand Pathway Activation? Gene Expression Signatures as Surrogate Markers for Understanding the Complexity of Pathway Activation

por Itadani, Hiraku, Mizuarai, Shinji, Kotani, Hidehito
Publicado 2008

Inhibition of p70S6K2 down-regulates Hedgehog/GLI pathway in non-small cell lung cancer cell lines

por Mizuarai, Shinji, Kawagishi, Aki, Kotani, Hidehito
Publicado 2009

Targeted disruption of H3 receptors results in changes in brain histamine tone leading to an obese phenotype

por Takahashi, Kazuhiko, Suwa, Hiroaki, Ishikawa, Tomoo, Kotani, Hidehito
Publicado 2002

Mouse gastric tumor models with prostaglandin E(2 )pathway activation show similar gene expression profiles to intestinal-type human gastric cancer

por Itadani, Hiraku, Oshima, Hiroko, Oshima, Masanobu, Kotani, Hidehito
Publicado 2009

Expression ratio of CCND1 to CDKN2A mRNA predicts RB1 status of cultured cancer cell lines and clinical tumor samples

por Mizuarai, Shinji, Machida, Takumitsu, Kobayashi, Tsutomu, Komatani, Hideya, Itadani, Hiraku, Kotani, Hidehito
Publicado 2011

Discovery of gene expression-based pharmacodynamic biomarker for a p53 context-specific anti-tumor drug Wee1 inhibitor

por Mizuarai Shinji, Yamanaka Kazunori, Itadani Hiraku, Arai Tsuyoshi, Nishibata Toshihide, Hirai Hiroshi, Kotani Hidehito
Publicado 2009-06-01

Discovery of gene expression-based pharmacodynamic biomarker for a p53 context-specific anti-tumor drug Wee1 inhibitor

por Mizuarai, Shinji, Yamanaka, Kazunori, Itadani, Hiraku, Arai, Tsuyoshi, Nishibata, Toshihide, Hirai, Hiroshi, Kotani, Hidehito
Publicado 2009

Crystal structures of the N-terminal kinase domain of human RSK1 bound to three different ligands: Implications for the design of RSK1 specific inhibitors

por Ikuta, Mari, Kornienko, Maria, Byrne, Noel, Reid, John C., Mizuarai, Shinji, Kotani, Hidehito, Munshi, Sanjeev K.
Publicado 2007

Enhanced Histaminergic Neurotransmission and Sleep-Wake Alterations, a Study in Histamine H3-Receptor Knock-Out Mice

por Gondard, Elise, Anaclet, Christelle, Akaoka, Hidéo, Guo, Rui-Xian, Zhang, Mei, Buda, Colette, Franco, Patricia, Kotani, Hidehito, Lin, Jian-Sheng
Publicado 2013

Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus

por Yoshimoto, Ryo, Miyamoto, Yasuhisa, Shimamura, Ken, Ishihara, Akane, Takahashi, Kazuhiko, Kotani, Hidehito, Chen, Airu S., Chen, Howard Y., MacNeil, Douglas J., Kanatani, Akio, Tokita, Shigeru
Publicado 2006