Tetrahydroisoquinoline CXCR4 Antagonists Adopt a Hybrid Binding Mode within the Peptide Subpocket of the CXCR4 Receptor

le Katzman, Brooke M., Cox, Bryan D., Prosser, Anthony R., Alcaraz, Ana A., Murat, Brigitte, Héroux, Madeleine, Tebben, Andrew, Zhang, Yong, Schroeder, Gretchen M., Snyder, James P., Wilson, Lawrence J., Liotta, Dennis C.
Foilsithe in ACS Med Chem Lett (2018)

In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure

le Gargalovic, Peter, Wong, Pancras, Onorato, Joelle, Finlay, Heather, Wang, Tao, Yan, Mujing, Crain, Earl, St-Onge, Stéphane, Héroux, Madeleine, Bouvier, Michel, Xu, Carrie, Chen, Xue-Qing, Generaux, Claudia, Lawrence, Michael, Wexler, Ruth, Gordon, David
Foilsithe in Circ Heart Fail (2021)

BRET-based effector membrane translocation assay monitors GPCR-promoted and endocytosis-mediated G(q) activation at early endosomes

le Wright, Shane C., Lukasheva, Viktoriya, Le Gouill, Christian, Kobayashi, Hiroyuki, Breton, Billy, Mailhot-Larouche, Samuel, Blondel-Tepaz, Élodie, Antunes Vieira, Nichelle, Costa-Neto, Claudio, Héroux, Madeleine, Lambert, Nevin A., Parreiras-e-Silva, Lucas Tabajara, Bouvier, Michel
Foilsithe in Proc Natl Acad Sci U S A (2021)

Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cells

le Volpi, Claudia, Mondanelli, Giada, Pallotta, Maria T., Vacca, Carmine, Iacono, Alberta, Gargaro, Marco, Albini, Elisa, Bianchi, Roberta, Belladonna, Maria L., Celanire, Sylvain, Mordant, Céline, Heroux, Madeleine, Royer-Urios, Isabelle, Schneider, Manfred, Vitte, Pierre-Alain, Cacquevel, Mathias, Galibert, Laurent, Poli, Sonia-Maria, Solari, Aldo, Bicciato, Silvio, Calvitti, Mario, Antognelli, Cinzia, Puccetti, Paolo, Orabona, Ciriana, Fallarino, Francesca, Grohmann, Ursula
Foilsithe in Neuropharmacology (2016)

Preservation of Post-Infarction Cardiac Structure and Function via Long-Term Oral Formyl Peptide Receptor Agonist Treatment

le García, Ricardo A., Ito, Bruce R., Lupisella, John A., Carson, Nancy A., Hsu, Mei-Yin, Fernando, Gayani, Heroux, Madeleine, Bouvier, Michel, Dierks, Elizabeth, Kick, Ellen K., Gordon, David A., Chen, Jian, Mintier, Gabe, Carrier, Marilyn, St-Onge, Stéphane, Shah, Himanshu, Towne, Jordan, Bucardo, Marcela Sotelo, Ma, Xiuying, Ryan, Carol S., Wurtz, Nicholas R., Ostrowski, Jacek, Villarreal, Francisco J.
Foilsithe in JACC Basic Transl Sci (2019)