Davis–Beirut Reaction: Route to Thiazolo-, Thiazino-, and Thiazepino-2H-indazoles

Por Farber, Kelli M., Haddadin, Makhluf J., Kurth, Mark J.
Publicado em 2014

Cell death by the quinoxaline dioxide DCQ in human colon cancer cells is enhanced under hypoxia and is independent of p53 and p21

Por El-Khatib, Mona, Geara, Fady, Haddadin, Makhluf J, Gali-Muhtasib, Hala
Publicado em 2010

The Davis-Beirut Reaction: N(1),N(2)-Disubstituted-1 H-Indazolones via 1,6-Electrophilic Addition to 3-Alkoxy-2H-Indazoles

Por Conrad, Wayne E., Fukazawa, Ryo, Haddadin, Makhluf J., Kurth, Mark J.
Publicado em 2011

Facile Syntheses of Novel Benzo-1,3-dioxolo-, Benzothiazolo-, Pyrido-, and Quinolino-fused 5H-Benzo[d]- pyrazolo[5,1-b][1,3]-oxazines and 1H-Pyrazoles

Por Avila, Belem, Solano, Danielle M., Haddadin, Makhluf J., Kurth, Mark J.
Publicado em 2011

Expedient one-pot synthesis of indolo[3,2-c]isoquinolines via a base-promoted N–alkylation/tandem cyclization

Por Nguyen, Huy H., Fettinger, James C., Haddadin, Makhluf J., Kurth, Mark J.
Publicado no Tetrahedron Lett (2015)

The radiosensitizer 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide induces DNA damage in EMT-6 mammary carcinoma cells

Por Haykal, Joelle, Geara, Fady, Haddadin, Makhluf J, Smith, Colin A, Gali-Muhtasib, Hala
Publicado em 2009

Photochemical Preparation of 1,2-Dihydro-3H-indazol-3-ones in Aqueous Solvent at Room Temperature

Por Zhu, Jie S., Kraemer, Niklas, Li, Clarabella J., Haddadin, Makhluf J., Kurth, Mark J.
Publicado no J Org Chem (2018)

Transannular Anti-Michael Addition: Formation of 4H-Pyrazolo[5,1-c]thiazines

Por Suen, Yat Fan, Hope, Håkon, Nantz, Michael H., Haddadin, Makhluf J., Kurth, and Mark J.
Publicado em 2006

Unusual Friedlander Reactions: a Route to Novel Quinoxaline-based Heterocycles ‡

Por Shoker, Tharallah A., Ghattass, Khaled I., Fettinger, James C., Kurth, Mark J., Haddadin, Makhluf J.
Publicado em 2012

Nucleophilic Substitution of Oxazino-/Oxazolino-/Benzoxazin- [3,2-b]indazoles: An Effective Route to 1 H-Indazolones

Por Donald, Michael B., Conrad, Wayne E., Oakdale, James S., Butler, Jeffrey D., Haddadin, Makhluf J., Kurth, Mark J.
Publicado em 2010

Diverting Reactive Intermediates Toward Unusual Chemistry – Unexpected Anthranil Products from Davis–Beirut Reaction

Por Zhu, Jie S., Son, Jung-Ho, Teuthorn, Andrew P., Haddadin, Makhluf J., Kurth, Mark J., Tantillo, Dean J.
Publicado no J Org Chem (2017)

Novel 2-(5-Imino-5H-isoquinolones[3,4-b]quinoxalin-7-ylmethyl)-benzonitrile (DIQ3) and Other Related Derivatives Targeting Colon Cancer Cells: Syntheses and in Vitro Models

Por Monzer, Alissar, Jabotian, Nayri, Ballout, Farah, Zhu, Jie S., Kurth, Mark J., Haddadin, Makhluf J., Gali-Muhtasib, Hala
Publicado no ACS Omega (2019)

A One-pot–Three-step Route to Triazolotriazepinoindazolones from Oxazolino-2H-indazoles

Por Conrad, Wayne E., Rodriguez, Kevin X., Nguyen, Huy H., Fettinger, James C., Haddadin, Makhluf J., Kurth, Mark J.
Publicado em 2012

The quinoxaline di-N-oxide DCQ blocks breast cancer metastasis in vitro and in vivo by targeting the hypoxia inducible factor-1 pathway

Por Ghattass, Khaled, El-Sitt, Sally, Zibara, Kazem, Rayes, Saide, Haddadin, Makhluf J, El-Sabban, Marwan, Gali-Muhtasib, Hala
Publicado em 2014

Acid and base catalyzed Davis-Beirut reaction: experimental and theoretical mechanistic studies and synthesis of novel 3-amino-2H-indazoles

Por Avila, Belem, El-Dakdouki, Mohammad H., Nazer, Musa Z., Harrison, Jason G., Tantillo, Dean J., Haddadin, Makhluf J., Kurth, Mark J.
Publicado em 2012

Dibenzonaphthyridinones: Heterocycle-to-Heterocycle Synthetic Strategies and Photophysical Studies

Por Palazzo, Teresa A., Patra, Digambara, Yang, Joung S., Khoury, Elsy El, Appleton, Mackenzie G., Haddadin, Makhluf J., Tantillo, Dean J., Kurth, Mark J.
Publicado no Org Lett (2015)

N─N Bond Formation between Primary Amines and Nitrosos: Direct Synthesis of 2-Substituted Indazolones with Mechanistic Insights

Por Zhu, Jie S., Kraemer, Niklas, Shatskikh, Marina E., Li, Clarabella J., Son, Jung-Ho, Haddadin, Makhluf J., Tantillo, Dean J., Kurth, Mark J.
Publicado no Org Lett (2018)

Inhibition of Myeloperoxidase: Evaluation of 2H-Indazoles and 1H-Indazolones

Por Roth, Aaron, Ott, Sean, Farber, Kelli M., Palazzo, Teresa A., Conrad, Wayne E., Haddadin, Makhluf J., Tantillo, Dean J., Cross, Carroll E., Eiserich, Jason P., Kurth, Mark J.
Publicado no Bioorg Med Chem (2014)