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Expedient one-pot synthesis of indolo[3,2-c]isoquinolines via a base-promoted N–alkylation/tandem cyclization
A transition metal-free, one-pot protocol has been developed for the synthesis of 11H-indolo[3,2-c]isoquinolin-5-amines via the atom economical annulation of ethyl (2-cyanophenyl)carbamates and 2-cyanobenzyl bromides. This method proceeds via sequential N–alkylation and base-promoted cyclization. Op...
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| Publicado no: | Tetrahedron Lett |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4564870/ https://ncbi.nlm.nih.gov/pubmed/26366017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2015.08.006 |
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