Functional aspects of primary cilia in signaling, cell cycle and tumorigenesis

Por Basten, Sander G, Giles, Rachel H
Publicado em 2013

The role of the cilium in hereditary tumor predisposition syndromes

Por Klasson, Timothy D., Giles, Rachel H.
Publicado no J Pediatr Genet (2014)

The SYSCILIA gold standard (SCGSv1) of known ciliary components and its applications within a systems biology consortium

Por van Dam, Teunis JP, Wheway, Gabrielle, Slaats, Gisela G, Huynen, Martijn A, Giles, Rachel H
Publicado em 2013

Lithium Causes G2 Arrest of Renal Principal Cells

Por de Groot, Theun, Alsady, Mohammad, Jaklofsky, Marcel, Otte-Höller, Irene, Baumgarten, Ruben, Giles, Rachel H., Deen, Peter M.T.
Publicado em 2014

LRRC50, a Conserved Ciliary Protein Implicated in Polycystic Kidney Disease

Por van Rooijen, Ellen, Giles, Rachel H., Voest, Emile E., van Rooijen, Carina, Schulte-Merker, Stefan, van Eeden, Freek J.
Publicado em 2008

Reduced cilia frequencies in human renal cell carcinomas versus neighboring parenchymal tissue

Por Basten, Sander G, Willekers, Sven, Vermaat, Joost SP, Slaats, Gisela GG, Voest, Emile E, van Diest, Paul J, Giles, Rachel H
Publicado em 2013

A role for central spindle proteins in cilia structure and function

Por Smith, Katherine R., Kieserman, Esther K., Wang, Peggy I., Basten, Sander G., Giles, Rachel H., Marcotte, Edward M., Wallingford, John B.
Publicado em 2011

Late Release of Circulating Endothelial Cells and Endothelial Progenitor Cells after Chemotherapy Predicts Response and Survival in Cancer Patients

Por Roodhart, Jeanine M, Langenberg, Marlies H, Vermaat, Joost S, Lolkema, Martijn P, Baars, Arnold, Giles, Rachel H, Witteveen, Els O, Voest, Emile E
Publicado em 2010

Human Embryonic Mesenchymal Stem Cell-Derived Conditioned Medium Rescues Kidney Function in Rats with Established Chronic Kidney Disease

Por van Koppen, Arianne, Joles, Jaap A., van Balkom, Bas W. M., Lim, Sai Kiang, de Kleijn, Dominique, Giles, Rachel H., Verhaar, Marianne C.
Publicado em 2012

Ex vivo exposure of bone marrow from chronic kidney disease donor rats to pravastatin limits renal damage in recipient rats with chronic kidney disease

Por van Koppen, Arianne, Papazova, Diana A, Oosterhuis, Nynke R, Gremmels, Hendrik, Giles, Rachel H, Fledderus, Joost O, Joles, Jaap A, Verhaar, Marianne C
Publicado no Stem Cell Res Ther (2015)

The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish

Por van der Velden, Yme U., Wang, Liqin, Zevenhoven, John, van Rooijen, Ellen, van Lohuizen, Maarten, Giles, Rachel H., Clevers, Hans, Haramis, Anna-Pavlina G.
Publicado em 2011

Pancreatic cyst development: insights from von Hippel-Lindau disease

Por van Asselt, Sophie J, de Vries, Elisabeth GE, van Dullemen, Hendrik M, Brouwers, Adrienne H, Walenkamp, Annemiek ME, Giles, Rachel H, Links, Thera P
Publicado em 2013

Presence of HIF-1 and related genes in normal mucosa, adenomas and carcinomas of the colorectum

Por Greijer, Astrid E., Delis-van Diemen, Pien M., Fijneman, Remond J. A., Giles, Rachel H., Voest, Emile E., van Hinsbergh, Victor W. M., Meijer, Gerrit A.
Publicado em 2008

The more we know, the more we have to discover: an exciting future for understanding cilia and ciliopathies

Por Benmerah, Alexandre, Durand, Bénédicte, Giles, Rachel H, Harris, Tess, Kohl, Linda, Laclef, Christine, Meilhac, Sigolène M, Mitchison, Hannah M, Pedersen, Lotte B, Roepman, Ronald, Swoboda, Peter, Ueffing, Marius, Bastin, Philippe
Publicado no Cilia (2015)

NEK8 Links the ATR-regulated Replication Stress Response and S-phase CDK Activity to Renal Ciliopathies

Por Choi, Hyo Jei Claudia, Lin, Jia-Ren, Vannier, Jean-Baptiste, Slaats, Gisela G., Kile, Andrew C., Paulsen, Renee D., Manning, Danielle K., Beier, David R., Giles, Rachel H., Boulton, Simon J., Cimprich, Karlene A.
Publicado em 2013

Screen-based identification and validation of four new ion channels as regulators of renal ciliogenesis

Por Slaats, Gisela G., Wheway, Gabrielle, Foletto, Veronica, Szymanska, Katarzyna, van Balkom, Bas W. M., Logister, Ive, Den Ouden, Krista, Keijzer-Veen, Mandy G., Lilien, Marc R., Knoers, Nine V., Johnson, Colin A., Giles, Rachel H.
Publicado no J Cell Sci (2015)

Rare disruptive mutations in ciliary function genes contribute to testicular cancer susceptibility

Por Litchfield, Kevin, Levy, Max, Dudakia, Darshna, Proszek, Paula, Shipley, Claire, Basten, Sander, Rapley, Elizabeth, Bishop, D. Timothy, Reid, Alison, Huddart, Robert, Broderick, Peter, Castro, David Gonzalez de, O'Connor, Simon, Giles, Rachel H., Houlston, Richard S., Turnbull, Clare
Publicado no Nat Commun (2016)

Joubert syndrome: genotyping a Northern European patient cohort

Por Kroes, Hester Y, Monroe, Glen R, van der Zwaag, Bert, Duran, Karen J, de Kovel, Carolien G, van Roosmalen, Mark J, Harakalova, Magdalena, Nijman, Ies J, Kloosterman, Wigard P, Giles, Rachel H, Knoers, Nine VAM, van Haaften, Gijs
Publicado no Eur J Hum Genet (2016)

Murine Joubert syndrome reveals Hedgehog signaling defects as a potential therapeutic target for nephronophthisis

Por Hynes, Ann Marie, Giles, Rachel H., Srivastava, Shalabh, Eley, Lorraine, Whitehead, Jennifer, Danilenko, Marina, Raman, Shreya, Slaats, Gisela G., Colville, John G., Ajzenberg, Henry, Kroes, Hester Y., Thelwall, Peter E., Simmons, Nicholas L., Miles, Colin G., Sayer, John A.
Publicado em 2014

Renal-Retinal Ciliopathy Gene Sdccag8 Regulates DNA Damage Response Signaling

Por Airik, Rannar, Slaats, Gisela G., Guo, Zhi, Weiss, Anna-Carina, Khan, Naheed, Ghosh, Amiya, Hurd, Toby W., Bekker-Jensen, Simon, Schrøder, Jacob M., Elledge, Steve J., Andersen, Jens S., Kispert, Andreas, Castelli, Maddalena, Boletta, Alessandra, Giles, Rachel H., Hildebrandt, Friedhelm
Publicado em 2014