Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking?

Yazar: Giembycz, M A
Baskı/Yayın Bilgisi 2008

Phosphodiesterase inhibitors: Lily the Pink's medicinal compound for asthma?

Yazar: Dent, G, Giembycz, M A
Baskı/Yayın Bilgisi 1996

Leukotriene D4 receptors are not negatively coupled to adenylyl cyclase in guinea-pig lung parenchyma.

Yazar: Giembycz, M. A., Diamond, J., Rodger, I. W.
Baskı/Yayın Bilgisi 1993

The long-acting β(2)-adrenoceptor agonist, indacaterol, enhances glucocorticoid receptor-mediated transcription in human airway epithelial cells in a gene- and agonist-dependent ma...

Yazar: Joshi, T, Johnson, M, Newton, R, Giembycz, M A
Yayımlandı Br J Pharmacol (2015)

Phosphodiesterase 4 in macrophages: relationship between cAMP accumulation, suppression of cAMP hydrolysis and inhibition of [3H]R-(-)-rolipram binding by selective inhibitors.

Yazar: Kelly, J J, Barnes, P J, Giembycz, M A
Baskı/Yayın Bilgisi 1996

A Holy Grail of asthma management: toward understanding how long-acting β(2)-adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids

Yazar: Giembycz, M A, Kaur, M, Leigh, R, Newton, R
Baskı/Yayın Bilgisi 2007

Early signalling events implicated in leukotriene B4-induced activation of the NADPH oxidase in eosinophils: role of Ca2+, protein kinase C and phospholipases C and D.

Yazar: Perkins, R S, Lindsay, M A, Barnes, P J, Giembycz, M A
Baskı/Yayın Bilgisi 1995

Cyclic AMP-elevating agents prolong or inhibit eosinophil survival depending on prior exposure to GM-CSF.

Yazar: Hallsworth, M. P., Giembycz, M. A., Barnes, P. J., Lee, T. H.
Baskı/Yayın Bilgisi 1996

Inhibition of eosinophil cyclic nucleotide PDE activity and opsonised zymosan-stimulated respiratory burst by 'type IV'-selective PDE inhibitors.

Yazar: Dent, G., Giembycz, M. A., Rabe, K. F., Barnes, P. J.
Baskı/Yayın Bilgisi 1991

Protein kinase C isoenzymes in airway smooth muscle.

Yazar: Webb, B L, Lindsay, M A, Barnes, P J, Giembycz, M A
Baskı/Yayın Bilgisi 1997

Effects of agents which elevate cyclic AMP on guinea-pig eosinophil homotypic aggregation.

Yazar: Teixeira, M. M., Rossi, A. G., Giembycz, M. A., Hellewell, P. G.
Baskı/Yayın Bilgisi 1996

Paradoxical facilitation of acetylcholine release from parasympathetic nerves innervating guinea-pig trachea by isoprenaline.

Yazar: Belvisi, M. G., Patel, H. J., Takahashi, T., Barnes, P. J., Giembycz, M. A.
Baskı/Yayın Bilgisi 1996

Identification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4+ and CD8+ T-lymphocytes: role in regulating proliferation and the biosynthesis of interleukin-2.

Yazar: Giembycz, M. A., Corrigan, C. J., Seybold, J., Newton, R., Barnes, P. J.
Baskı/Yayın Bilgisi 1996

In vitro and in vivo effect of verapamil on human airway responsiveness to leukotriene D4.

Yazar: Roberts, J A, Giembycz, M A, Raeburn, D, Rodger, I W, Thomson, N C
Baskı/Yayın Bilgisi 1986

Lack of effect of zaprinast on methacholine-induced contraction and inositol 1,4,5-trisphosphate accumulation in bovine tracheal smooth muscle.

Yazar: Chilvers, E. R., Giembycz, M. A., Challiss, R. A., Barnes, B. J., Nahorski, S. R.
Baskı/Yayın Bilgisi 1991

Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells

Yazar: Holden, N S, Gong, W, King, E M, Kaur, M, Giembycz, M A, Newton, R
Baskı/Yayın Bilgisi 2007

Possible role of cyclic AMP phosphodiesterases in the actions of ibudilast on eosinophil thromboxane generation and airways smooth muscle tone.

Yazar: Souness, J. E., Villamil, M. E., Scott, L. C., Tomkinson, A., Giembycz, M. A., Raeburn, D.
Baskı/Yayın Bilgisi 1994

Inhibitory effect of p38 mitogen-activated protein kinase inhibitors on cytokine release from human macrophages

Yazar: Smith, S J, Fenwick, P S, Nicholson, A G, Kirschenbaum, F, Finney-Hayward, T K, Higgins, L S, Giembycz, M A, Barnes, P J, Donnelly, L E
Baskı/Yayın Bilgisi 2006