Use of mRNA expression signatures to discover small molecule inhibitors of skeletal muscle atrophy

por Adams, Christopher M., Ebert, Scott M., Dyle, Michael C.
Publicado en Curr Opin Clin Nutr Metab Care (2015)

Pericyte transplantation improves skeletal muscle recovery following hindlimb immobilization

por Munroe, Michael, Dvoretskiy, Svyatoslav, Lopez, Amber, Leong, Jiayu, Dyle, Michael C., Kong, Hyunjoon, Adams, Christopher M., Boppart, Marni D.
Publicado en FASEB J (2019)

Ursolic Acid Increases Skeletal Muscle and Brown Fat and Decreases Diet-Induced Obesity, Glucose Intolerance and Fatty Liver Disease

por Kunkel, Steven D., Elmore, Christopher J., Bongers, Kale S., Ebert, Scott M., Fox, Daniel K., Dyle, Michael C., Bullard, Steven A., Adams, Christopher M.
Publicado 2012

Skeletal muscle denervation causes skeletal muscle atrophy through a pathway that involves both Gadd45a and HDAC4

por Bongers, Kale S., Fox, Daniel K., Ebert, Scott M., Kunkel, Steven D., Dyle, Michael C., Bullard, Steven A., Dierdorff, Jason M., Adams, Christopher M.
Publicado 2013

p53 and ATF4 mediate distinct and additive pathways to skeletal muscle atrophy during limb immobilization

por Fox, Daniel K., Ebert, Scott M., Bongers, Kale S., Dyle, Michael C., Bullard, Steven A., Dierdorff, Jason M., Kunkel, Steven D., Adams, Christopher M.
Publicado 2014

Stress-induced Skeletal Muscle Gadd45a Expression Reprograms Myonuclei and Causes Muscle Atrophy

por Ebert, Scott M., Dyle, Michael C., Kunkel, Steven D., Bullard, Steven A., Bongers, Kale S., Fox, Daniel K., Dierdorff, Jason M., Foster, Eric D., Adams, Christopher M.
Publicado 2012

Systems-based Discovery of Tomatidine as a Natural Small Molecule Inhibitor of Skeletal Muscle Atrophy

por Dyle, Michael C., Ebert, Scott M., Cook, Daniel P., Kunkel, Steven D., Fox, Daniel K., Bongers, Kale S., Bullard, Steven A., Dierdorff, Jason M., Adams, Christopher M.
Publicado 2014

Gadd45a Protein Promotes Skeletal Muscle Atrophy by Forming a Complex with the Protein Kinase MEKK4

por Bullard, Steven A., Seo, Seongjin, Schilling, Birgit, Dyle, Michael C., Dierdorff, Jason M., Ebert, Scott M., DeLau, Austin D., Gibson, Bradford W., Adams, Christopher M.
Publicado en J Biol Chem (2016)

Spermine oxidase maintains basal skeletal muscle gene expression and fiber size and is strongly repressed by conditions that cause skeletal muscle atrophy

por Bongers, Kale S., Fox, Daniel K., Kunkel, Steven D., Stebounova, Larissa V., Murry, Daryl J., Pufall, Miles A., Ebert, Scott M., Dyle, Michael C., Bullard, Steven A., Dierdorff, Jason M., Adams, Christopher M.
Publicado en Am J Physiol Endocrinol Metab (2014)

Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy

por Ebert, Scott M., Dyle, Michael C., Bullard, Steven A., Dierdorff, Jason M., Murry, Daryl J., Fox, Daniel K., Bongers, Kale S., Lira, Vitor A., Meyerholz, David K., Talley, John J., Adams, Christopher M.
Publicado en J Biol Chem (2015)

Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness

por Sharma, Arpit, Oonthonpan, Lalita, Sheldon, Ryan D, Rauckhorst, Adam J, Zhu, Zhiyong, Tompkins, Sean C, Cho, Kevin, Grzesik, Wojciech J, Gray, Lawrence R, Scerbo, Diego A, Pewa, Alvin D, Cushing, Emily M, Dyle, Michael C, Cox, James E, Adams, Chris, Davies, Brandon S, Shields, Richard K, Norris, Andrew W, Patti, Gary, Zingman, Leonid V, Taylor, Eric B
Publicado en eLife (2019)