Discovery of Potent and Orally Bioavailable Small Molecule Antagonists of Toll-like Receptors 7/8/9 (TLR7/8/9)

von Mussari, Christopher P., Dodd, Dharmpal S., Sreekantha, Ratna Kumar, Pasunoori, Laxman, Wan, Honghe, Posy, Shana L., Critton, David, Ruepp, Stefan, Subramanian, Murali, Watson, Andrew, Davies, Paul, Schieven, Gary L., Salter-Cid, Luisa M., Srivastava, Ratika, Tagore, Debarati Mazumder, Dudhgaonkar, Shailesh, Poss, Michael A., Carter, Percy H., Dyckman, Alaric J.
Veröffentlicht in ACS Med Chem Lett (2020)

Aryl Ether-Derived Sphingosine-1-Phosphate Receptor (S1P(1)) Modulators: Optimization of the PK, PD, and Safety Profiles

von Xiao, Zili, Yang, Michael G., Dhar, T. G. Murali, Xiao, Hai-Yun, Gilmore, John L., Marcoux, David, McIntyre, Kim W., Taylor, Tracy L., Shi, Hong, Levesque, Paul C., Marino, Anthony M., Cornelius, Georgia, Mathur, Arvind, Shen, Ding Ren, Cvijic, Mary Ellen, Lehman-McKeeman, Lois D., Sun, Huadong, Xie, Jenny H., Carter, Percy H., Dyckman, Alaric J.
Veröffentlicht in ACS Med Chem Lett (2020)

Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P(1) Receptor Modulator in Clinical Trials

von Dhar, T. G. Murali, Xiao, Hai-Yun, Xie, Jenny, Lehman-McKeeman, Lois D., Wu, Dauh-Rurng, Dabros, Marta, Yang, Xiaoxia, Taylor, Tracy L., Zhou, Xia D., Heimrich, Elizabeth M., Thomas, Rochelle, McIntyre, Kim W., Warrack, Bethanne, Shi, Hong, Levesque, Paul C., Zhu, Jia L., Hennan, James, Balimane, Praveen, Yang, Zheng, Marino, Anthony M., Cornelius, Georgia, D’Arienzo, Celia J., Mathur, Arvind, Shen, Ding Ren, Cvijic, Mary Ellen, Salter-Cid, Luisa, Barrish, Joel C., Carter, Percy H., Dyckman, Alaric J.
Veröffentlicht in ACS Med Chem Lett (2016)

Identification of potent tricyclic prodrug S1P(1) receptor modulators

von Marcoux, David, Xiao, Hai-Yun, Murali Dhar, T. G., Xie, Jenny, Lehman-McKeeman, Lois D., Wu, Dauh-Rurng, Dabros, Marta, Yang, Xiaoxia, Taylor, Tracy L., Zhou, Xia D., Heimrich, Elizabeth M., Thomas, Rochelle, McIntyre, Kim W., Shi, Hong, Levesque, Paul C., Sun, Huadong, Yang, Zheng, Marino, Anthony M., Cornelius, Georgia, D'Arienzo, Celia J., Gupta, Anuradha, Pragalathan, Bala, Rampulla, Richard, Mathur, Arvind, Shen, Ding Ren, Cvijic, Mary Ellen, Salter-Cid, Luisa, Lombardo, Louis J., Carter, Percy H., Dyckman, Alaric J.
Veröffentlicht in Medchemcomm (2016)