Discovery of Potent and Orally Bioavailable Small Molecule Antagonists of Toll-like Receptors 7/8/9 (TLR7/8/9)

[Image: see text] The toll-like receptor (TLR) family is an evolutionarily conserved component of the innate immune system, responsible for the early detection of foreign or endogenous threat signals. In the context of autoimmunity, the unintended recognition of self-motifs as foreign promotes initi...

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Opis bibliograficzny
Wydane w:ACS Med Chem Lett
Główni autorzy: Mussari, Christopher P., Dodd, Dharmpal S., Sreekantha, Ratna Kumar, Pasunoori, Laxman, Wan, Honghe, Posy, Shana L., Critton, David, Ruepp, Stefan, Subramanian, Murali, Watson, Andrew, Davies, Paul, Schieven, Gary L., Salter-Cid, Luisa M., Srivastava, Ratika, Tagore, Debarati Mazumder, Dudhgaonkar, Shailesh, Poss, Michael A., Carter, Percy H., Dyckman, Alaric J.
Format: Artigo
Język:Inglês
Wydane: American Chemical Society 2020
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488287/
https://ncbi.nlm.nih.gov/pubmed/32944143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00264
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