Discovery of Potent and Orally Bioavailable Small Molecule Antagonists of Toll-like Receptors 7/8/9 (TLR7/8/9)

[Image: see text] The toll-like receptor (TLR) family is an evolutionarily conserved component of the innate immune system, responsible for the early detection of foreign or endogenous threat signals. In the context of autoimmunity, the unintended recognition of self-motifs as foreign promotes initi...

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محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:ACS Med Chem Lett
المؤلفون الرئيسيون: Mussari, Christopher P., Dodd, Dharmpal S., Sreekantha, Ratna Kumar, Pasunoori, Laxman, Wan, Honghe, Posy, Shana L., Critton, David, Ruepp, Stefan, Subramanian, Murali, Watson, Andrew, Davies, Paul, Schieven, Gary L., Salter-Cid, Luisa M., Srivastava, Ratika, Tagore, Debarati Mazumder, Dudhgaonkar, Shailesh, Poss, Michael A., Carter, Percy H., Dyckman, Alaric J.
التنسيق: Artigo
اللغة:Inglês
منشور في: American Chemical Society 2020
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488287/
https://ncbi.nlm.nih.gov/pubmed/32944143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00264
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