Drug binding and resistance mechanism of KIT tyrosine kinase revealed by hydrogen/deuterium exchange FTICR mass spectrometry

di Zhang, Hui-Min, Yu, Xiu, Greig, Michael J, Gajiwala, Ketan S, Wu, Joe C, Diehl, Wade, Lunney, Elizabeth A, Emmett, Mark R, Marshall, Alan G
Pubblicazione 2010

Crystallographic Identification of a Noncompetitive Inhibitor Binding Site on the Hepatitis C Virus NS5B RNA Polymerase Enzyme

di Love, Robert A., Parge, Hans E., Yu, Xiu, Hickey, Michael J., Diehl, Wade, Gao, Jingjin, Wriggers, Hilary, Ekker, Anne, Wang, Liann, Thomson, James A., Dragovich, Peter S., Fuhrman, Shella A.
Pubblicazione 2003

Crystallographic Identification of a Noncompetitive Inhibitor Binding Site on the Hepatitis C Virus NS5B RNA Polymerase Enzyme

di Love, Robert A., Parge, Hans E., Yu, Xiu, Hickey, Michael J., Diehl, Wade, Gao, Jingjin, Wriggers, Hilary, Ekker, Anne, Wang, Liann, Thomson, James A., Dragovich, Peter S., Fuhrman, Shella A.
Pubblicazione 2003

Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance

di Brooun, Alexei, Gajiwala, Ketan S., Deng, Ya-Li, Liu, Wei, Bolaños, Ben, Bingham, Patrick, He, You-Ai, Diehl, Wade, Grable, Nicole, Kung, Pei-Pei, Sutton, Scott, Maegley, Karen A., Yu, Xiu, Stewart, Al E.
Pubblicato in Nat Commun (2016)

KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients

di Gajiwala, Ketan S., Wu, Joe C., Christensen, James, Deshmukh, Gayatri D., Diehl, Wade, DiNitto, Jonathan P., English, Jessie M., Greig, Michael J., He, You-Ai, Jacques, Suzanne L., Lunney, Elizabeth A., McTigue, Michele, Molina, David, Quenzer, Terri, Wells, Peter A., Yu, Xiu, Zhang, Yan, Zou, Aihua, Emmett, Mark R., Marshall, Alan G., Zhang, Hui-Min, Demetri, George D.
Pubblicazione 2009