The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases.

par Dennis, P B, Pullen, N, Kozma, S C, Thomas, G
Publié 1996

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

par Jefferies, H B, Fumagalli, S, Dennis, P B, Reinhard, C, Pearson, R B, Thomas, G
Publié 1997

The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p7...

par von Manteuffel, S R, Dennis, P B, Pullen, N, Gingras, A C, Sonenberg, N, Thomas, G
Publié 1997

The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.

par Pearson, R B, Dennis, P B, Han, J W, Williamson, N A, Kozma, S C, Wettenhall, R E, Thomas, G
Publié 1995

Dual requirement for a newly identified phosphorylation site in p70s6k.

par Moser, B A, Dennis, P B, Pullen, N, Pearson, R B, Williamson, N A, Wettenhall, R E, Kozma, S C, Thomas, G
Publié 1997