Evolutionary and molecular foundations of multiple contemporary functions of the nitroreductase superfamily

by Akiva, Eyal, Copp, Janine N., Tokuriki, Nobuhiko, Babbitt, Patricia C.
Published in Proc Natl Acad Sci U S A (2017)

The Flavin Reductase MsuE Is a Novel Nitroreductase that Can Efficiently Activate Two Promising Next-Generation Prodrugs for Gene-Directed Enzyme Prodrug Therapy

by Green, Laura K., Storey, Mathew A., Williams, Elsie M., Patterson, Adam V., Smaill, Jeff B., Copp, Janine N., Ackerley, David F.
Published 2013

Intracellular complexities of acquiring a new enzymatic function revealed by mass-randomisation of active-site residues

by Hall, Kelsi R, Robins, Katherine J, Williams, Elsie M, Rich, Michelle H, Calcott, Mark J, Copp, Janine N, Little, Rory F, Schwörer, Ralf, Evans, Gary B, Patrick, Wayne M, Ackerley, David F
Published in eLife (2020)

Mechanistic Understanding Enables the Rational Design of Salicylanilide Combination Therapies for Gram-Negative Infections

by Copp, Janine N., Pletzer, Daniel, Brown, Alistair S., Van der Heijden, Joris, Miton, Charlotte M., Edgar, Rebecca J., Rich, Michelle H., Little, Rory F., Williams, Elsie M., Hancock, Robert E. W., Tokuriki, Nobuhiko, Ackerley, David F.
Published in mBio (2020)

A revised biosynthetic pathway for the cofactor F(420) in prokaryotes

by Bashiri, Ghader, Antoney, James, Jirgis, Ehab N. M., Shah, Mihir V., Ney, Blair, Copp, Janine, Stuteley, Stephanie M., Sreebhavan, Sreevalsan, Palmer, Brian, Middleditch, Martin, Tokuriki, Nobuhiko, Greening, Chris, Scott, Colin, Baker, Edward N., Jackson, Colin J.
Published in Nat Commun (2019)

E. coli nitroreductase NfsA is a reporter gene for non-invasive PET imaging in cancer gene therapy applications

by Mowday, Alexandra Marie, Copp, Janine Naomi, Syddall, Sophie Philippa, Dubois, Ludwig Jerome, Wang, Jingli, Lieuwes, Natasja Gabi, Biemans, Rianne, Ashoorzadeh, Amir, Abbattista, Maria Rosaria, Williams, Elsie May, Guise, Christopher Paul, Lambin, Philippe, Ackerley, David Francis, Smaill, Jeff Bruce, Theys, Jan, Patterson, Adam Vorn
Published in Theranostics (2020)