Mechanism of Two-/Four-Electron Reduction of Nitroaromatics by Oxygen-Insensitive Nitroreductases: The Role of a Non-Enzymatic Reduction Step

por Valiauga, Benjaminas, Misevičienė, Lina, Rich, Michelle H., Ackerley, David F., Šarlauskas, Jonas, Čėnas, Narimantas
Publicado no Molecules (2018)

Engineering the Escherichia coli Nitroreductase NfsA to Create a Flexible Enzyme-Prodrug Activation System

por Sharrock, Abigail V., McManaway, Sarah P., Rich, Michelle H., Mumm, Jeff S., Hermans, Ian F., Tercel, Moana, Pruijn, Frederik B., Ackerley, David F.
Publicado no Front Pharmacol (2021)

Intracellular complexities of acquiring a new enzymatic function revealed by mass-randomisation of active-site residues

por Hall, Kelsi R, Robins, Katherine J, Williams, Elsie M, Rich, Michelle H, Calcott, Mark J, Copp, Janine N, Little, Rory F, Schwörer, Ralf, Evans, Gary B, Patrick, Wayne M, Ackerley, David F
Publicado no eLife (2020)

Mechanistic Understanding Enables the Rational Design of Salicylanilide Combination Therapies for Gram-Negative Infections

por Copp, Janine N., Pletzer, Daniel, Brown, Alistair S., Van der Heijden, Joris, Miton, Charlotte M., Edgar, Rebecca J., Rich, Michelle H., Little, Rory F., Williams, Elsie M., Hancock, Robert E. W., Tokuriki, Nobuhiko, Ackerley, David F.
Publicado no mBio (2020)