Evolutionary and molecular foundations of multiple contemporary functions of the nitroreductase superfamily

Autor Akiva, Eyal, Copp, Janine N., Tokuriki, Nobuhiko, Babbitt, Patricia C.
Vydáno v Proc Natl Acad Sci U S A (2017)

The Flavin Reductase MsuE Is a Novel Nitroreductase that Can Efficiently Activate Two Promising Next-Generation Prodrugs for Gene-Directed Enzyme Prodrug Therapy

Autor Green, Laura K., Storey, Mathew A., Williams, Elsie M., Patterson, Adam V., Smaill, Jeff B., Copp, Janine N., Ackerley, David F.
Vydáno 2013

Intracellular complexities of acquiring a new enzymatic function revealed by mass-randomisation of active-site residues

Autor Hall, Kelsi R, Robins, Katherine J, Williams, Elsie M, Rich, Michelle H, Calcott, Mark J, Copp, Janine N, Little, Rory F, Schwörer, Ralf, Evans, Gary B, Patrick, Wayne M, Ackerley, David F
Vydáno v eLife (2020)

Mechanistic Understanding Enables the Rational Design of Salicylanilide Combination Therapies for Gram-Negative Infections

Autor Copp, Janine N., Pletzer, Daniel, Brown, Alistair S., Van der Heijden, Joris, Miton, Charlotte M., Edgar, Rebecca J., Rich, Michelle H., Little, Rory F., Williams, Elsie M., Hancock, Robert E. W., Tokuriki, Nobuhiko, Ackerley, David F.
Vydáno v mBio (2020)

A revised biosynthetic pathway for the cofactor F(420) in prokaryotes

Autor Bashiri, Ghader, Antoney, James, Jirgis, Ehab N. M., Shah, Mihir V., Ney, Blair, Copp, Janine, Stuteley, Stephanie M., Sreebhavan, Sreevalsan, Palmer, Brian, Middleditch, Martin, Tokuriki, Nobuhiko, Greening, Chris, Scott, Colin, Baker, Edward N., Jackson, Colin J.
Vydáno v Nat Commun (2019)

E. coli nitroreductase NfsA is a reporter gene for non-invasive PET imaging in cancer gene therapy applications

Autor Mowday, Alexandra Marie, Copp, Janine Naomi, Syddall, Sophie Philippa, Dubois, Ludwig Jerome, Wang, Jingli, Lieuwes, Natasja Gabi, Biemans, Rianne, Ashoorzadeh, Amir, Abbattista, Maria Rosaria, Williams, Elsie May, Guise, Christopher Paul, Lambin, Philippe, Ackerley, David Francis, Smaill, Jeff Bruce, Theys, Jan, Patterson, Adam Vorn
Vydáno v Theranostics (2020)