RNA-mediated pathogenic mechanisms in polyglutamine diseases and amyotrophic lateral sclerosis

por Chan, Ho Yin Edwin
Publicado en Front Cell Neurosci (2014)

A mechanism for reversible mesoscopic aggregation in liquid solutions

por Chan, Ho Yin, Lubchenko, Vassiliy
Publicado en Nat Commun (2019)

Drosophila melanogaster As a Model Organism to Study RNA Toxicity of Repeat Expansion-Associated Neurodegenerative and Neuromuscular Diseases

por Koon, Alex C., Chan, Ho Yin Edwin
Publicado en Front Cell Neurosci (2017)

Transcriptional dysregulation in neurodegenerative diseases: who tipped the balance of Yin Yang 1 in the brain?

por Chen, Zhefan Stephen, Chan, Ho Yin Edwin
Publicado en Neural Regen Res (2019)

Anisotropy of the Coulomb Interaction between Folded Proteins: Consequences for Mesoscopic Aggregation of Lysozyme

por Chan, Ho Yin, Lankevich, Vladimir, Vekilov, Peter G., Lubchenko, Vassiliy
Publicado 2012

Lack of Dependence of the Sizes of the Mesoscopic Protein Clusters on Electrostatics

por Vorontsova, Maria A., Chan, Ho Yin, Lubchenko, Vassiliy, Vekilov, Peter G.
Publicado en Biophys J (2015)

A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3

por Chen, Zhefan Stephen, Huang, Xiaoying, Talbot, Kevin, Chan, Ho Yin Edwin
Publicado en Cell Death Dis (2021)

Pan-cancer investigation reveals mechanistic insights of planar cell polarity gene Fuz in carcinogenesis

por Chen, Zhefan Stephen, Lin, Xiao, Chan, Ting-Fung, Chan, Ho Yin Edwin
Publicado en Aging (Albany NY) (2021)

COVID-19, community response, public policy, and travel patterns: A tale of Hong Kong

por Chan, Ho-Yin, Chen, Anthony, Ma, Wei, Sze, Nang-Ngai, Liu, Xintao
Publicado en Transp Policy (Oxf) (2021)

Expanded polyalanine tracts function as nuclear export signals and promote protein mislocalization via eEF1A1 factor

por Li, Li, Ng, Nelson Ka Lam, Koon, Alex Chun, Chan, Ho Yin Edwin
Publicado en J Biol Chem (2017)

Co-Encapsulation and Co-Delivery of Peptide Drugs via Polymeric Nanoparticles

por Kim, Ma Rie, Feng, Teng, Zhang, Qian, Chan, Ho Yin Edwin, Chau, Ying
Publicado en Polymers (Basel) (2019)

The SARS-Coronavirus Membrane protein induces apoptosis through modulating the Akt survival pathway

por Chan, Chak-Ming, Ma, Cheuk-Wing, Chan, Wood-Yee, Chan, Ho Yin Edwin
Publicado en Arch Biochem Biophys (2007)

Polycrystalline-Diamond MEMS Biosensors Including Neural Microelectrode-Arrays

por Varney, Michael W., Aslam, Dean M., Janoudi, Abed, Chan, Ho-Yin, Wang, Donna H.
Publicado en Biosensors (Basel) (2011)

Isolation and Identification of a Novel Anti-protein Aggregation Activity of Lignin-Carbohydrate Complex From Chionanthus retusus Leaves

por Pei, Wenhui, Chen, Zhefan Stephen, Chan, Ho Yin Edwin, Zheng, Liming, Liang, Chen, Huang, Caoxing
Publicado en Front Bioeng Biotechnol (2020)

CAG expansion induces nucleolar stress in polyglutamine diseases

por Tsoi, Ho, Lau, Terrence Chi-Kong, Tsang, Suk-Ying, Lau, Kwok-Fai, Chan, Ho Yin Edwin
Publicado 2012

Crystal structure of the SENP1 mutant C603S–SUMO complex reveals the hydrolytic mechanism of SUMO-specific protease

por Xu, Zheng, Chau, So Fun, Lam, Kwok Ho, Chan, Ho Yin, Ng, Tzi Bun, Au, Shannon W. N.
Publicado 2006

Improving Atomic Force Microscopy Imaging by a Direct Inverse Asymmetric PI Hysteresis Model

por Wang, Dong, Yu, Peng, Wang, Feifei, Chan, Ho-Yin, Zhou, Lei, Dong, Zaili, Liu, Lianqing, Li, Wen Jung
Publicado en Sensors (Basel) (2015)

GULP1/CED-6 ameliorates amyloid-β toxicity in a Drosophila model of Alzheimer’s disease

por Vivien Chiu, Wai Yin, Koon, Alex Chun, Ki Ngo, Jacky Chi, Edwin Chan, Ho Yin, Lau, Kwok-Fai
Publicado en Oncotarget (2017)

Whole-genome sequencing of two probands with hereditary spastic paraplegia reveals novel splice-donor region variant and known pathogenic variant in SPG11

por Yu, Allen Chi-Shing, Chan, Anne Yin-Yan, Au, Wing Chi, Shen, Yun, Chan, Ting Fung, Chan, Ho-Yin Edwin
Publicado en Cold Spring Harb Mol Case Stud (2016)

A Peptidylic Inhibitor for Neutralizing (r)(GGGGCC)(exp)-Associated Neurodegeneration in C9ALS-FTD

por Zhang, Qian, An, Ying, Chen, Zhefan Stephen, Koon, Alex Chun, Lau, Kwok-Fai, Ngo, Jacky Chi Ki, Chan, Ho Yin Edwin
Publicado en Mol Ther Nucleic Acids (2019)