Key analogs of a uniquely potent synthetic vinblastine that contain modifications of the C20′ ethyl substituent

по Allemann, Oliver, Cross, R. Matthew, Brütsch, Manuela M., Radakovic, Aleksandar, Boger, Dale L.
Опубликовано в: Bioorg Med Chem Lett (2017)

Ultrapotent vinblastines in which added molecular complexity further disrupts the target tubulin dimer–dimer interface

по Carney, Daniel W., Lukesh, John C., Brody, Daniel M., Brütsch, Manuela M., Boger, Dale L.
Опубликовано в: Proc Natl Acad Sci U S A (2016)

Total synthesis of a key series of vinblastines modified at C4 that define the importance and surprising trends in activity

по Yang, Shouliang, Sankar, Kuppusamy, Skepper, Colin K., Barker, Timothy J., Lukesh III, John C., Brody, Daniel M., Brütsch, Manuela M., Boger, Dale L.
Опубликовано в: Chem Sci (2017)

Vinblastine 20’ Amides: Synthetic Analogs That Maintain or Improve Potency and Simultaneously Overcome Pgp-derived Efflux and Resistance

по Lukesh, John C., Carney, Daniel W., Dong, Huijun, Cross, R. Matthew, Shukla, Vyom, Duncan, Katharine K., Yang, Shouliang, Brody, Daniel M., Brütsch, Manuela M., Radakovic, Aleksandar, Boger, Dale L.
Опубликовано в: J Med Chem (2017)