Key analogs of a uniquely potent synthetic vinblastine that contain modifications of the C20′ ethyl substituent

par Allemann, Oliver, Cross, R. Matthew, Brütsch, Manuela M., Radakovic, Aleksandar, Boger, Dale L.
Publié dans Bioorg Med Chem Lett (2017)

Ultrapotent vinblastines in which added molecular complexity further disrupts the target tubulin dimer–dimer interface

par Carney, Daniel W., Lukesh, John C., Brody, Daniel M., Brütsch, Manuela M., Boger, Dale L.
Publié dans Proc Natl Acad Sci U S A (2016)

Total synthesis of a key series of vinblastines modified at C4 that define the importance and surprising trends in activity

par Yang, Shouliang, Sankar, Kuppusamy, Skepper, Colin K., Barker, Timothy J., Lukesh III, John C., Brody, Daniel M., Brütsch, Manuela M., Boger, Dale L.
Publié dans Chem Sci (2017)

Vinblastine 20’ Amides: Synthetic Analogs That Maintain or Improve Potency and Simultaneously Overcome Pgp-derived Efflux and Resistance

par Lukesh, John C., Carney, Daniel W., Dong, Huijun, Cross, R. Matthew, Shukla, Vyom, Duncan, Katharine K., Yang, Shouliang, Brody, Daniel M., Brütsch, Manuela M., Radakovic, Aleksandar, Boger, Dale L.
Publié dans J Med Chem (2017)