Key analogs of a uniquely potent synthetic vinblastine that contain modifications of the C20′ ethyl substituent

بواسطة Allemann, Oliver, Cross, R. Matthew, Brütsch, Manuela M., Radakovic, Aleksandar, Boger, Dale L.
الحاوية / القاعدة Bioorg Med Chem Lett (2017)

Ultrapotent vinblastines in which added molecular complexity further disrupts the target tubulin dimer–dimer interface

بواسطة Carney, Daniel W., Lukesh, John C., Brody, Daniel M., Brütsch, Manuela M., Boger, Dale L.
الحاوية / القاعدة Proc Natl Acad Sci U S A (2016)

Total synthesis of a key series of vinblastines modified at C4 that define the importance and surprising trends in activity

بواسطة Yang, Shouliang, Sankar, Kuppusamy, Skepper, Colin K., Barker, Timothy J., Lukesh III, John C., Brody, Daniel M., Brütsch, Manuela M., Boger, Dale L.
الحاوية / القاعدة Chem Sci (2017)

Vinblastine 20’ Amides: Synthetic Analogs That Maintain or Improve Potency and Simultaneously Overcome Pgp-derived Efflux and Resistance

بواسطة Lukesh, John C., Carney, Daniel W., Dong, Huijun, Cross, R. Matthew, Shukla, Vyom, Duncan, Katharine K., Yang, Shouliang, Brody, Daniel M., Brütsch, Manuela M., Radakovic, Aleksandar, Boger, Dale L.
الحاوية / القاعدة J Med Chem (2017)