Mycobacterial cell wall biosynthesis: a multifaceted antibiotic target

Por ABRAHAMS, KATHERINE A., BESRA, GURDYAL S.
Publicado no Parasitology (2018)

Modular Synthesis of Diverse Natural Product‐Like Macrocycles: Discovery of Hits with Antimycobacterial Activity

Por Dow, Mark, Marchetti, Francesco, Abrahams, Katherine A., Vaz, Luis, Besra, Gurdyal S., Warriner, Stuart, Nelson, Adam
Publicado no Chemistry (2017)

Development of a whole‐cell high‐throughput phenotypic screen to identify inhibitors of mycobacterial amino acid biosynthesis

Por Burke, Christopher, Abrahams, Katherine A., Richardson, Emily J., Loman, Nicholas J., Alemparte, Carlos, Lelievre, Joel, Besra, Gurdyal S.
Publicado no FASEB Bioadv (2019)

Anti-tubercular derivatives of rhein require activation by the monoglyceride lipase Rv0183

Por Abrahams, Katherine A., Hu, Wei, Li, Gang, Lu, Yu, Richardson, Emily J., Loman, Nicholas J., Huang, Haihong, Besra, Gurdyal S.
Publicado no Cell Surf (2020)

Mycobacterial Dihydrofolate Reductase Inhibitors Identified Using Chemogenomic Methods and In Vitro Validation

Por Mugumbate, Grace, Abrahams, Katherine A., Cox, Jonathan A. G., Papadatos, George, van Westen, Gerard, Lelièvre, Joël, Calus, Szymon T., Loman, Nicholas J., Ballell, Lluis, Barros, David, Overington, John P., Besra, Gurdyal S.
Publicado no PLoS One (2015)

Identification of Novel Imidazo[1,2-a]pyridine Inhibitors Targeting M. tuberculosis QcrB

Por Abrahams, Katherine A., Cox, Jonathan A. G., Spivey, Vickey L., Loman, Nicholas J., Pallen, Mark J., Constantinidou, Chrystala, Fernández, Raquel, Alemparte, Carlos, Remuiñán, Modesto J., Barros, David, Ballell, Lluis, Besra, Gurdyal S.
Publicado em 2012

Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface

Por Abrahams, Katherine A., Cox, Jonathan A. G., Fütterer, Klaus, Rullas, Joaquín, Ortega-Muro, Fátima, Loman, Nicholas J., Moynihan, Patrick J., Pérez-Herrán, Esther, Jiménez, Elena, Esquivias, Jorge, Barros, David, Ballell, Lluís, Alemparte, Carlos, Besra, Gurdyal S.
Publicado no Sci Rep (2017)

Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen

Por Cox, Jonathan A. G., Mugumbate, Grace, Del Peral, Laura Vela-Glez, Jankute, Monika, Abrahams, Katherine A., Jervis, Peter, Jackenkroll, Stefan, Perez, Arancha, Alemparte, Carlos, Esquivias, Jorge, Lelièvre, Joël, Ramon, Fernando, Barros, David, Ballell, Lluis, Besra, Gurdyal S.
Publicado no Sci Rep (2016)

Biochemical and Structural Characterization of Mycobacterial Aspartyl-tRNA Synthetase AspS, a Promising TB Drug Target

Por Gurcha, Sudagar S., Usha, Veeraraghavan, Cox, Jonathan A. G., Fütterer, Klaus, Abrahams, Katherine A., Bhatt, Apoorva, Alderwick, Luke J., Reynolds, Robert C., Loman, Nicholas J., Nataraj, VijayaShankar, Alemparte, Carlos, Barros, David, Lloyd, Adrian J., Ballell, Lluis, Hobrath, Judith V., Besra, Gurdyal S.
Publicado no PLoS One (2014)

Identification of KasA as the cellular target of an anti-tubercular scaffold

Por Abrahams, Katherine A., Chung, Chun-wa, Ghidelli-Disse, Sonja, Rullas, Joaquín, Rebollo-López, María José, Gurcha, Sudagar S., Cox, Jonathan A. G., Mendoza, Alfonso, Jiménez-Navarro, Elena, Martínez-Martínez, María Santos, Neu, Margarete, Shillings, Anthony, Homes, Paul, Argyrou, Argyrides, Casanueva, Ruth, Loman, Nicholas J., Moynihan, Patrick J., Lelièvre, Joël, Selenski, Carolyn, Axtman, Matthew, Kremer, Laurent, Bantscheff, Marcus, Angulo-Barturen, Iñigo, Izquierdo, Mónica Cacho, Cammack, Nicholas C., Drewes, Gerard, Ballell, Lluis, Barros, David, Besra, Gurdyal S., Bates, Robert H.
Publicado no Nat Commun (2016)