Resultados da pesquisa - ((drug (dosen OR dosn)) OR (drug dose)) devel ther*

181

Comparison of the long-term efficacy and safety of generic tacrolimus, Tacrobell, with Prograf in liver transplant recipients

Por Choi, Ho Joong, Kim, Dong Goo, Kwak, Bong Jun, Han, Jae Hyun, Hong, Tae Ho, You, Young Kyoung
Publicado no Drug Des Devel Ther (2018)

“... evaluated the relationship between drug dose and trough level, survival, rejection, infection, kidney...”
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182

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Pharmacokinetic interactions and tolerability of berberine chloride with simvastatin and fenofibrate: an open-label, randomized, parallel study in healthy Chinese subjects

Por Li, Guofei, Zhao, Mingming, Qiu, Feng, Sun, Yaxin, Zhao, Limei
Publicado no Drug Des Devel Ther (2018)

“... lipid-lowering drug that is widely used in the treatment of hypercholesterolemia...”
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183

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Review of deutetrabenazine: a novel treatment for chorea associated with Huntington’s disease

Por Dean, Marissa, Sung, Victor W
Publicado no Drug Des Devel Ther (2018)

“...) and is the first deuterated medication that has been US Food and Drug Administration (FDA)-approved for therapeutic...”
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184

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An open-label, two-period comparative study on pharmacokinetics and safety of a combined ethinylestradiol/gestodene transdermal contraceptive patch

Por Zhang, Chao, Li, Haiyan, Xiong, Xin, Zhai, Suodi, Wei, Yudong, Zhang, Shuang, Zhang, Yuanyuan, Xu, Lin, Liu, Li
Publicado no Drug Des Devel Ther (2017)

“... ethinylestradiol (EE)/gestodene (GSD) transdermal contraceptive patch after a single-dose administration...”
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185

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Sample sizes in dosage investigational clinical trials: a systematic evaluation

Por Huang, Ji-Han, Su, Qian-Min, Yang, Juan, Lv, Ying-Hua, He, Ying-Chun, Chen, Jun-Chao, Xu, Ling, Wang, Kun, Zheng, Qing-Shan
Publicado no Drug Des Devel Ther (2015)

“... and effective doses. However, as yet, there is no clear rule and no related published literature about...”
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186

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Comparative bioequivalence studies of tramadol hydrochloride sustained-release 200 mg tablets

Por Khandave, Suhas S, Sawant, Satish V, Joshi, Santosh S, Bansal, Yatish K, Kadam, Sonal S
Publicado em 2010

“..., and 300 mg sustained-release (SR) tablets. The recommended dose of tramadol is 50–100 mg IR tablets every...”
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187

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Tacrolimus in preventing transplant rejection in Chinese patients – optimizing use

Por Li, Chuan-Jiang, Li, Liang
Publicado no Drug Des Devel Ther (2015)

“... inhibitors. It is a widely used immunosuppressive drug for preventing solid-organ transplant rejection...”
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188

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The influence of intrauterine exposure to immunosuppressive treatment on changes in the immune system in juvenile Wistar rats

Por Kabat-Koperska, Joanna, Kolasa-Wołosiuk, Agnieszka, Wojciuk, Bartosz, Wojciechowska-Koszko, Iwona, Roszkowska, Paulina, Krasnodębska-Szponder, Barbara, Paczkowska, Edyta, Safranow, Krzysztof, Gołembiewska, Edyta, Machaliński, Bogusław, Ciechanowski, Kazimierz
Publicado no Drug Des Devel Ther (2016)

“... on 40 (32+8) female Wistar rats administered full and half dose of drugs, respectively, subjected...”
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189

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Efficacy and safety of a herbal mixture (Viron(®) tablets) in the treatment of patients with chronic hepatitis C virus infection: a prospective, randomized, open-label, proof-of-co...

Por Shawkat, Hisham, Yakoot, Mostafa, Shawkat, Tarek, Helmy, Sherine
Publicado no Drug Des Devel Ther (2015)

“... infection is believed to require the combination of different drug classes to provide good antiviral...”
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190

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Pharmacokinetic characteristics of telaprevir in healthy Korean male subjects and comparisons with Japanese

Por Choi, Yewon, Yoon, Seonghae, Matsumoto, Kyoko, Ohta, Yoshiyasu, Lee, SeungHwan, Yu, Kyung-Sang, Jang, In-Jin
Publicado no Drug Des Devel Ther (2018)

“... in Japanese male subjects. METHODS: The single ascending dose study was conducted in 3 dose-based groups (500...”
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191

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$A Phase I study of an intravesically administered immunotoxin targeting EpCAM for the treatment of nonmuscle-invasive bladder cancer in BCGrefractory and BCG-intolerant patients$

A Phase I study of an intravesically administered immunotoxin targeting EpCAM for the treatment of nonmuscle-invasive bladder cancer in BCGrefractory and BCG-intolerant patients

Por Kowalski, Mark, Entwistle, Joycelyn, Cizeau, Jeannick, Niforos, Demi, Loewen, Shauna, Chapman, Wendy, MacDonald, Glen C
Publicado em 2010

“... to or intolerant of BCG therapy, were enrolled. Treatment was administered in ascending dose cohorts ranging from...”
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192

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Development and targeted use of nilotinib in chronic myeloid leukemia

Por Fava, Carmen, Kantarjian, Hagop, Cortes, Jorge, Jabbour, Elias
Publicado em 2009

“... the problem of imatinib resistance, including imatinib dose escalation, novel targeted agents and combination...”
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193

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A review of sitagliptin with special emphasis on its use in moderate to severe renal impairment

Por Eligar, Vinay S, Bain, Stephen C
Publicado em 2013

“... diabetes. It is widely used as an add-on therapy to ongoing management or as monotherapy where it is deemed...”
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194

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Pharmacokinetics and tolerability of the new second-generation nonnucleoside reverse- transcriptase inhibitor KM-023 in healthy subjects

Por Cha, Yu-Jung, Lim, Kyoung Soo, Park, Min-Kyu, Schneider, Stephen, Bray, Brian, Kang, Myung-Chol, Chung, Jae-Yong, Yoon, Seo Hyun, Cho, Joo-Youn, Yu, Kyung-Sang
Publicado em 2014

“... AND METHODS: A randomized, double-blinded, placebo-controlled, dose-escalation study was conducted in 80...”
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195

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Discovery and evaluation of novel anti-inflammatory derivatives of natural bioactive curcumin

Por Zhang, Yali, Jiang, Xin, Peng, Kesong, Chen, Chengwei, Fu, Lili, Wang, Zhe, Feng, Jianpeng, Liu, Zhiguo, Zhang, Huajie, Liang, Guang, Pan, Zheer
Publicado no Drug Des Devel Ther (2014)

“... dose-dependent manner and also displayed excellent stability and low cytotoxicity in vitro. In addition...”
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196

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Pharmacokinetics, pharmacodynamics and safety of CKD-519, a CETP inhibitor, in healthy subjects

Por Kim, Choon Ok, Oh, Eun Sil, Choi, Chungam, Kim, Yeonjoo, Lee, Sera, Kim, Semi, Park, Min Soo
Publicado no Drug Des Devel Ther (2016)

“... the safety, tolerability, pharmacokinetics, and pharmacodynamics of single doses of CKD-519 in healthy adult...”
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197

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A phase I clinical study of VB4-845: Weekly intratumoral administration of an anti-EpCAM recombinant fusion protein in patients with squamous cell carcinoma of the head and neck

Por MacDonald, Glen C, Rasamoelisolo, Michèle, Entwistle, Joycelyn, Cizeau, Jeannick, Bosc, Denis, Cuthbert, Wendy, Kowalski, Mark, Spearman, Maureen, Glover, Nick
Publicado em 2009

“... molecule (EpCAM). A phase I trial was conducted to determine the maximum tolerated dose (MTD) of VB4-845...”
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198

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Eltrombopag for the treatment of aplastic anemia: current perspectives

Por Lum, Su Han, Grainger, John D
Publicado no Drug Des Devel Ther (2016)

“... resulting in cytopenia. The mainstays of treatment for AA are definitive therapy to restore HSCs...”
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199

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Formulation and in vitro characterization of rifampicin-loaded porous poly (ε-caprolactone) microspheres for sustained skeletal delivery

Por Mei, Quanjing, Luo, Peipei, Zuo, Yi, Li, Jidong, Zou, Qin, Li, Yubao, Jiang, Dianming, Wang, Yaning
Publicado no Drug Des Devel Ther (2018)

“... of the peculiarity of skeletal system and liver damage caused by high-dose administration. In this research, a porous...”
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200

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Reevaluation of the post-marketing safety of Shuxuening injection based on real-world and evidence-based evaluations

Por Wang, Can, Shi, Qing-ping, Ding, Feng, Jiang, Xiao-dong, Tang, Wei, Yu, Mei-Ling, Zhu, Jian-Hua
Publicado no Drug Des Devel Ther (2018)

“... and suspected allergic reactions. Randomized controlled studies and cohort studies of the adverse drug reaction...”
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