Resultados da pesquisa - (( j epac amp camp new ) OR ((( a pascual computer case non ) OR ( _ nato compared

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Functional Analysis beyond Enrichment: Non-Redundant Reciprocal Linkage of Genes and Biological Terms

Por Fontanillo, Celia, Nogales-Cadenas, Ruben, Pascual-Montano, Alberto, De Las Rivas, Javier
Publicado em 2011

“... we could not find an equivalent method, we present a comparative analysis with a widely used method...”
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Cell physiology of cAMP sensor Epac

Por Holz, George G, Kang, Guoxin, Harbeck, Mark, Roe, Michael W, Chepurny, Oleg G
Publicado em 2006

“...Epac is an acronym for the exchange proteins activated directly by cyclic AMP, a family of cAMP...”
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Identifying functional groups among the diverse, recombining antigenic var genes of the malaria parasite Plasmodium falciparum from a local community in Ghana

Por Rorick, Mary M., Baskerville, Edward B., Rask, Thomas S., Day, Karen P., Pascual, Mercedes
Publicado no PLoS Comput Biol (2018)

“... the evolutionary history of a gene family; however phylogenetic approaches are not possible in cases where gene...”
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Executing Complexity-Increasing Queries in Relational (MySQL) and NoSQL (MongoDB and EXist) Size-Growing ISO/EN 13606 Standardized EHR Databases

Por Sánchez-de-Madariaga, Ricardo, Muñoz, Adolfo, Castro, Antonio L, Moreno, Oscar, Pascual, Mario
Publicado no J Vis Exp (2018)

“...-increasing queries were computed, and the results showed a linear behavior in the NoSQL cases. In the NoSQL...”
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Epac-Selective cAMP Analogs: New Tools With Which To Evaluate The Signal Transduction Properties Of cAMP-Regulated Guanine Nucleotide Exchange Factors

Por Holz, George G., Chepurny, Oleg G., Schwede, Frank
Publicado em 2007

“... of Epac. A wealth of newly published studies demonstrate that 8-pCPT-2′-O-Me-cAMP is a unique tool...”
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Exchange proteins directly activated by cAMP (EPACs): Emerging therapeutic targets

Por Wang, Pingyuan, Liu, Zhiqing, Chen, Haiying, Ye, Na, Cheng, Xiaodong, Zhou, Jia
Publicado no Bioorg Med Chem Lett (2017)

“...Exchange proteins directly activated by cAMP (EPACs) are critical cAMP-dependent signaling pathway...”
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Economic Analysis of Combined Endoscopic and Endobronchial Ultrasound in the Evaluation of Patients with Suspected Non-Small Cell Lung Cancer

Por Harewood, Gavin C., Pascual, Jorge, Raimondo, Massimo, Woodward, Timothy, Johnson, Margaret, McComb, Barbara, Odell, John, Jamil, Laith H., Gill, Kanwar Rupinder S., Wallace, Michael B.
Publicado em 2009

“... cancer (NSCLC). Researchers used a cost-minimization model to compare various diagnostic approaches...”
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SNR and Standard Deviation of cGNSS-R and iGNSS-R Scatterometric Measurements

Por Alonso-Arroyo, Alberto, Querol, Jorge, Lopez-Martinez, Carlos, Zavorotny, Valery U., Park, Hyuk, Pascual, Daniel, Onrubia, Raul, Camps, Adriano
Publicado no Sensors (Basel) (2017)

“.... The coherent component is present for some type of surfaces, and it has been neglected until now because...”
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The cAMP-responsive Rap1 Guanine Nucleotide Exchange Factor, Epac, Induces Smooth Muscle Relaxation by Down-regulation of RhoA Activity

Por Zieba, Bartosz J., Artamonov, Mykhaylo V., Jin, Li, Momotani, Ko, Ho, Ruoya, Franke, Aaron S., Neppl, Ronald L., Stevenson, Andra S., Khromov, Alexander S., Chrzanowska-Wodnicka, Magdalena, Somlyo, Avril V.
Publicado em 2011

“...)) phosphorylation and force. Cyclic nucleotides can reverse this process. We report a new mechanism of cAMP-mediated...”
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Identification of a Tetrahydroquinoline Analog as a Pharmacological Inhibitor of the cAMP-binding Protein Epac

Por Courilleau, Delphine, Bisserier, Malik, Jullian, Jean-Christophe, Lucas, Alexandre, Bouyssou, Pascal, Fischmeister, Rodolphe, Blondeau, Jean-Paul, Lezoualc'h, Frank
Publicado em 2012

“...-cAMP, an Epac-selective agonist, or isoprenaline, a non-selective β-adrenergic receptor agonist. Our...”
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Exposure to cAMP and β-adrenergic stimulation recruits Ca(V)3 T-type channels in rat chromaffin cells through Epac cAMP-receptor proteins

Por Novara, M, Baldelli, P, Cavallari, D, Carabelli, V, Giancippoli, A, Carbone, E
Publicado em 2004

“...–5 days after application of pCPT-cAMP, most RCCs grown in serum-free medium expressed a high density...”
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The Epac-Rap1 Signaling Pathway Controls cAMP-mediated Exocytosis of Weibel-Palade Bodies in Endothelial Cells

Por van Hooren, Kathinka W. E. M., van Agtmaal, Ellen L., Fernandez-Borja, Mar, van Mourik, Jan A., Voorberg, Jan, Bierings, Ruben
Publicado em 2012

“..., these data uncover a new Epac-Rap1-dependent pathway by which endothelial cells can regulate WPB exocytosis...”
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Direct Activation of Epac by Sulfonylurea is Isoform Selective

Por Herbst, Katie J., Coltharp, Carla, Amzel, L. Mario, Zhang, Jin
Publicado em 2011

“... in SU binding. This distinct binding site from cAMP points to a new mode of allosteric activation...”
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A mTurquoise-Based cAMP Sensor for Both FLIM and Ratiometric Read-Out Has Improved Dynamic Range

Por Klarenbeek, Jeffrey B., Goedhart, Joachim, Hink, Mark A., Gadella, Theodorus W. J., Jalink, Kees
Publicado em 2011

“.... In this study, we present a new cAMP sensor, termed (T)Epac(VV), which employs mTurquoise as donor. Spectrally...”
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The cAMP binding protein Epac modulates Ca(2+) sparks by a Ca(2+)/calmodulin kinase signalling pathway in rat cardiac myocytes

Por Pereira, Laetitia, Métrich, Mélanie, Fernández-Velasco, María, Lucas, Alexandre, Leroy, Jérôme, Perrier, Romain, Morel, Eric, Fischmeister, Rodolphe, Richard, Sylvain, Bénitah, Jean-Pierre, Lezoualc'h, Frank, Gómez, Ana María
Publicado em 2007

“...). The identification of a cAMP binding protein, Epac, raises the question of its role in Ca(2+) signalling in cardiac...”
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The EPAC–Rap1 pathway prevents and reverses cytokine-induced retinal vascular permeability

Por Ramos, Carla J., Lin, Chengmao, Liu, Xuwen, Antonetti, David A.
Publicado no J Biol Chem (2018)

“... vascular permeability and restore the blood–retinal barrier (BRB) may lead to new therapies. The cAMP...”
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Epac-Rap Signaling Reduces Oxidative Stress in the Tubular Epithelium

Por Stokman, Geurt, Qin, Yu, Booij, Tijmen H., Ramaiahgari, Sreenivasa, Lacombe, Marie, Dolman, M. Emmy M., van Dorenmalen, Kim M.A., Teske, Gwendoline J.D., Florquin, Sandrine, Schwede, Frank, van de Water, Bob, Kok, Robbert J., Price, Leo S.
Publicado em 2014

“...Activation of Rap1 by exchange protein activated by cAMP (Epac) promotes cell adhesion and actin...”
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Structure-activity relationships of 2-substituted phenyl-N-phenyl-2-oxoacetohydrazonoyl cyanides as novel antagonists of exchange proteins directly activated by cAMP (EPACs)

Por Liu, Zhiqing, Zhu, Yingmin, Chen, Haiying, Wang, Pingyuan, Mei, Fang C., Ye, Na, Cheng, Xiaodong, Zhou, Jia
Publicado no Bioorg Med Chem Lett (2017)

“...Exchange proteins directly activated by cAMP (EPACs) are critical cAMP-dependent signaling pathway...”
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cAMP Regulation of Airway Smooth Muscle Function

Por Billington, Charlotte K., Ojo, Oluwaseun O., Penn, Raymond B., Ito, Satoru
Publicado em 2012

“... and cAMP signal, have raised new and interesting questions about these well-studied molecules...”
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Guanine nucleotide exchange factor Epac2–dependent activation of the GTP-binding protein Rap2A mediates cAMP-dependent growth arrest in neuroendocrine cells

Por Emery, Andrew C., Xu, Wenqin, Eiden, Maribeth V., Eiden, Lee E.
Publicado no J Biol Chem (2017)

“.... Three cAMP sensors, Epac2, PKA, and neuritogenic cAMP sensor–Rapgef2, mediate distinct cellular outputs...”
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