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1

Revisiting Five Years of CASMI Contests with EPA Identification Tools

Revisiting Five Years of CASMI Contests with EPA Identification Tools

Por McEachran, Andrew D., Chao, Alex, Al-Ghoul, Hussein, Lowe, Charles, Grulke, Christopher, Sobus, Jon R., Williams, Antony J.
Publicado no Metabolites (2020)

“... screening studies. The US Environmental Protection Agency’s (EPA) CompTox Chemicals Dashboard is now...”
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2

Kinetic mechanism of Toxoplasma gondii adenosine kinase and the highly efficient utilization of adenosine

Kinetic mechanism of Toxoplasma gondii adenosine kinase and the highly efficient utilization of adenosine

Por Naguib, Fardos N. M., Rais, Reem H., Al Safarjalani, Omar N., el Kouni, Mahmoud H.
Publicado no Comp Biochem Physiol B Biochem Mol Biol (2015)

“... generates three new AMPs. These findings along with the fact that a wide range of nucleoside 5′-mono, di...”
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3

A Constellation of Orthopaedic Deformities in Connection with Cartilage Oligomeric Matrix Protein Mutation

A Constellation of Orthopaedic Deformities in Connection with Cartilage Oligomeric Matrix Protein Mutation

Por Al Kaissi, Ali, Ghachem, Maher Ben, Kenis, Vladimir, Melchenko, Eugene, Grill, Franz, Ganger, Rudolf, Kircher, Susanne Gerit
Publicado no Afr J Paediatr Surg (2019)

“...BACKGROUND: Trendelenburg's gait can be observed in Legg-Calvé-Perthes disease, antalgic gait...”
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4

Generalised Read-Across (GenRA): A workflow implemented into the EPA CompTox Chemicals Dashboard

Generalised Read-Across (GenRA): A workflow implemented into the EPA CompTox Chemicals Dashboard

Por Helman, George, Shah, Imran, Williams, Antony J., Edwards, Jeff, Dunne, Jeremy, Patlewicz, Grace
Publicado no ALTEX (2019)

“... described in more detail in the literature (Shah et al., 2016; Helman et al., 2018). Here we present its...”
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5

Regenerative and fibrotic pathways in canine hepatic portosystemic shunt and portal vein hypoplasia, new models for clinical hepatocyte growth factor treatment

Regenerative and fibrotic pathways in canine hepatic portosystemic shunt and portal vein hypoplasia, new models for clinical hepatocyte growth factor treatment

Por Spee, Bart, Penning, Louis C, van den Ingh, Ted SGAM, Arends, Brigitte, IJzer, Jooske, van Sluijs, Frederik J, Rothuizen, Jan
Publicado em 2005

“... that intracellular signaling components (protein kinase B/Akt, ERK1/2, and STAT3) were functional. The TGF-β1 mRNA...”
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6

Hormonal and synaptic influences of serotonin on adult neurogenesis

Hormonal and synaptic influences of serotonin on adult neurogenesis

Por Benton, J.L., Goergen, E.M., Rogan, S.C., Beltz, B.S.
Publicado em 2008

“... of suppressing neurogenesis; (3) previously demonstrated (Beltz et al., 2001) serotonergic fibers from the dorsal...”
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7

Human neural progenitor cells generated from induced pluripotent stem cells can survive, migrate, and integrate in the rodent spinal cord

Human neural progenitor cells generated from induced pluripotent stem cells can survive, migrate, and integrate in the rodent spinal cord

Por Sareen, Dhruv, Gowing, Geneviève, Sahabian, Anais, Staggenborg, Kevin, Paradis, Renée, Avalos, Pablo, Latter, Jessica, Ornelas, Loren, Garcia, Leslie, Svendsen, Clive N.
Publicado em 2014

“... we describe a new and abundant source of NPCs derived from human induced pluripotent stem cells...”
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8

Identification of the Proteins, Including MAGEG1, That Make Up the Human SMC5-6 Protein Complex

Identification of the Proteins, Including MAGEG1, That Make Up the Human SMC5-6 Protein Complex

Por Taylor, Elaine M., Copsey, Alice C., Hudson, Jessica J. R., Vidot, Susanne, Lehmann, Alan R.
Publicado em 2008

“...The SMC protein complexes play important roles in chromosome dynamics. The function of the SMC5-6...”
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9

Targeting of Hematin by the Antimalarial Pyronaridine

Targeting of Hematin by the Antimalarial Pyronaridine

Por Auparakkitanon, Saranya, Chapoomram, Soebsakul, Kuaha, Kannika, Chirachariyavej, Thamrong, Wilairat, Prapon
Publicado em 2006

“...Pyronaridine, 2-methoxy-7-chloro-10[3′,5′-bis(pyrrolidinyl-1-methyl-)4′hydroxyphenyl]aminobenzyl-(b...”
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10

The role of sterol-C4-methyl oxidase in epidermal biology

The role of sterol-C4-methyl oxidase in epidermal biology

Por He, Miao, Smith, Laurie D., Chang, Richard, Li, Xueli, Vockley, Jerry
Publicado em 2013

“...Deficiency of sterol C4 methyl oxidase, encoded by the SC4MOL gene, has recently been described...”
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11

Effects of n-alkanols and a methyl ester on a transient potassium (IA) current in identified neurones from Helix aspersa.

Effects of n-alkanols and a methyl ester on a transient potassium (IA) current in identified neurones from Helix aspersa.

Por Winpenny, J P, Elliott, J R, Harper, A A
Publicado em 1992

“... of action in the cell of -3.1 +/- 0.2 kJ/mol. This suggested a hydrophobic site or sites of action...”
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12

Neuroprotection by estrogen against MPP(+)-induced dopamine neuron death is mediated by ERα in primary cultures of mouse mesencephalon

Neuroprotection by estrogen against MPP(+)-induced dopamine neuron death is mediated by ERα in primary cultures of mouse mesencephalon

Por Bains, Mona, Cousins, Joanne C., Roberts, James L.
Publicado em 2007

“...Estrogen involvement in neuroprotection is now widely accepted, although the specific molecular...”
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13

Bioassay for Determining the Concentrations of Caffeine and Individual Methylxanthines in Complex Samples

Bioassay for Determining the Concentrations of Caffeine and Individual Methylxanthines in Complex Samples

Por Gutierrez, Alejandro E., Shah, Prachi, Rex, Abigail E., Nguyen, Tien C., Kenkare, Saamiha P., Barrick, Jeffrey E., Mishler, Dennis M.
Publicado no Appl Environ Microbiol (2019)

“...-demethylation pathway from Pseudomonas putida CBB5, these bacteria demethylate caffeine (1,3,7-trimethylxanthine...”
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14

The metabolic advantage of tumor cells

The metabolic advantage of tumor cells

Por Schwartz Laurent, Israël Maurice
Publicado em 2011-06-01

“... result from PP2A methylation, which then attenuates kinases.</p> <p>3- Moreover, kinases activated...”
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15

The metabolic advantage of tumor cells

The metabolic advantage of tumor cells

Por Israël, Maurice, Schwartz, Laurent
Publicado em 2011

“..., fetal-genes-M2, increase) 5- IGFBP stops binding the IGF - IGFR complex, it is perhaps no longer...”
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16

Neuronal DNA content variation (DCV) with regional and individual differences in the human brain

Neuronal DNA content variation (DCV) with regional and individual differences in the human brain

Por Westra, Jurjen W., Rivera, Richard R., Bushman, Diane M., Yung, Yun C., Peterson, Suzanne E., Barral, Serena, Chun, Jerold
Publicado em 2010

“... that the vertebrate brain can be genomically heterogeneous (Rehen et al., 2001; Rehen et al., 2005; Westra et al...”
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17

Anti-tumour activities of a new benzo[c]phenanthridine agent, 2,3-(methylenedioxy)-5-methyl-7-hydroxy-8-methoxybenzo[c]phena nthridini um hydrogensulphate dihydrate (NK109), against several drug-resistant human tumour cell lines.

Anti-tumour activities of a new benzo[c]phenanthridine agent, 2,3-(methylenedioxy)-5-methyl-7...

Por Kanzawa, F., Nishio, K., Ishida, T., Fukuda, M., Kurokawa, H., Fukumoto, H., Nomoto, Y., Fukuoka, K., Bojanowski, K., Saijo, N.
Publicado em 1997

“..., it is very important to develop new drugs that are effective against drug-resistant tumour cells. The novel...”
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18

Interpretable correlation descriptors for quantitative structure-activity relationships

Interpretable correlation descriptors for quantitative structure-activity relationships

Por Spowage, Benson M, Bruce, Craig L, Hirst, Jonathan D
Publicado em 2009

“... in previous QSAR studies. CONCLUSIONS: The TMACC interpretation can provide new insight into the structure...”
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19

Potential role of LSD1 inhibitors in the treatment of sickle cell disease: a review of preclinical animal model data

Potential role of LSD1 inhibitors in the treatment of sickle cell disease: a review of preclinical animal model data

Por Rivers, Angela, Jagadeeswaran, Ramasamy, Lavelle, Donald
Publicado no Am J Physiol Regul Integr Comp Physiol (2018)

“... expectancy (Rees DC, et al. Lancet 376: 2018–2031, 2010; Serjeant GR. Cold Spring Harb Perspect Med 3: a...”
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20

The free radical scavenger Trolox dampens neuronal hyperexcitability, reinstates synaptic plasticity, and improves hypoxia tolerance in a mouse model of Rett syndrome

The free radical scavenger Trolox dampens neuronal hyperexcitability, reinstates synaptic plasticity, and improves hypoxia tolerance in a mouse model of Rett syndrome

Por Janc, Oliwia A., Müller, Michael
Publicado em 2014

“... disturbances with intermittent hypoxia. Also mitochondria are affected; a subunit of respiratory complex III...”
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