Resultados da pesquisa - (( drug does develop them ) OR ((( drug doses give further ) OR ( drug noise level theory ))))

1

Naphthoquinone Derivatives as Scaffold to Develop New Drugs for Tuberculosis Treatment

Por Halicki, Priscila C. B., Ferreira, Laís A., De Moura, Kelly C. G., Carneiro, Paula F., Del Rio, Karina P., Carvalho, Tatiane dos S. C., Pinto, Maria do C. F. R., da Silva, Pedro E. A., Ramos, Daniela F.
Publicado no Front Microbiol (2018)

“... of resistant Mycobacterium tuberculosis strains. These barriers reinforcing the need for development of new...”
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Drug-induced hypothermia in stroke models: does it always protect?

Por Zhang, Meijuan, Wang, Haiying, Zhao, Jinbing, Chen, Cong, Leak, Rehana K., Xu, Yun, Vosler, Peter, Gao, Yanqin, Zhang, Feng
Publicado em 2013

“... alternative worthy of further clinical development. We begin this review with a brief introduction...”
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Photochemically Controlled Drug Dosing from a Polymeric Scaffold

Por Donnelly, Louise, Hardy, John G., Gorman, Sean P., Jones, David S., Irwin, Nicola J., McCoy, Colin P.
Publicado no Pharm Res (2017)

“...PURPOSE: To develop the first photoactive biomaterial coating capable of controlled drug dosing via...”
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Young people who inject drugs in Mozambique: should we emphasize them in the National Harm Reduction Plan?

Por Semá Baltazar, Cynthia, Boothe, Makini, Kellogg, Timothy
Publicado no Harm Reduct J (2020)

“...Mozambique has one of the highest burdens of HIV globally, and people who inject drugs (PWID) have...”
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Quantum mechanics implementation in drug-design workflows: does it really help?

Por Arodola, Olayide A, Soliman, Mahmoud ES
Publicado no Drug Des Devel Ther (2017)

“... them into drug-design and -discovery workflows while trying to answer a critical question: are QM-based...”
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A strategy for effective latent HIV reactivation using subtherapeutic drug doses

Por Cotterell, James, Neely, G. Gregory
Publicado no Sci Rep (2017)

“... dose much further than has previously been thought possible yet still maintaining efficacy....”
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Computer support for determining drug dose: systematic review and meta-analysis

Por Walton, Robert, Dovey, Susan, Harvey, Emma, Freemantle, Nick
Publicado em 1999

“... the correct dose of certain drugs in acute hospital settings is beneficial. Computers may give doctors...”
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The value of assessing cognitive function in drug development

Por Wesnes, Keith A.
Publicado em 2000

“...This paper reviews the value and utility of measuring cognitive function in the development of new...”
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Population Pharmacokinetics and Bayesian Dose Adjustment to Advance TDM of Anti-TB Drugs

Por Sturkenboom, Marieke G. G., Märtson, Anne-Grete, Svensson, Elin M., Sloan, Derek J., Dooley, Kelly E., van den Elsen, Simone H. J., Denti, Paolo, Peloquin, Charles A., Aarnoutse, Rob E., Alffenaar, Jan-Willem C.
Publicado no Clin Pharmacokinet (2021)

“... anti-TB drugs. Since the introduction of therapeutic drug monitoring for TB over 3 decades ago, further...”
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Further pharmacology and chemotherapy of cloxacillin

Por Acred, P., Brown, D. M.
Publicado em 1963

“...In concentrations greatly in excess of therapeutic blood levels cloxacillin has a slight...”
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3D-Printed Isoniazid Tablets for the Treatment and Prevention of Tuberculosis—Personalized Dosing and Drug Release

Por Öblom, Heidi, Zhang, Jiaxiang, Pimparade, Manjeet, Speer, Isabell, Preis, Maren, Repka, Michael, Sandler, Niklas
Publicado no AAPS PharmSciTech (2019)

“...The aim of the present work was to produce 3D-printed oral dosage forms with a sufficient drug dose...”
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Novel Dosing Strategies Increase Exposures of the Potent Antituberculosis Drug Rifapentine but Are Poorly Tolerated in Healthy Volunteers

Por Dooley, Kelly E., Savic, Radojka M., Park, Jeong-Gun, Cramer, Yoninah, Hafner, Richard, Hogg, Evelyn, Janik, Jennifer, Marzinke, Mark A., Patterson, Kristine, Benson, Constance A., Hovind, Laura, Dorman, Susan E., Haas, David W.
Publicado no Antimicrob Agents Chemother (2015)

“... exposures: dividing the dose or giving the drug with a high-fat meal. In arm 1, rifapentine was administered...”
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Developing micro-/nanoparticulate drug delivery systems using “design of experiments”

Por Singh, Bhupinder, Bhatowa, Rahul, Tripathi, Chandra Bhushan, Kapil, Rishi
Publicado em 2011

“... approach “Design of Experiments (DoE)” as applicable to formulation development of microparticles...”
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Amtolmetin guacil: is it possible to develop an "advanced" NSAID?

Por A. E. Karateyev
Publicado em 2013-12-01

Assuntos: “...nonsteroidal anti-inflammatory drugs...”
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Nuclear Export of Phosphorylated Galectin-3 Regulates Its Antiapoptotic Activity in Response to Chemotherapeutic Drugs

Por Takenaka, Yukinori, Fukumori, Tomoharu, Yoshii, Tadashi, Oka, Natsuo, Inohara, Hidenori, Kim, Hyeong-Reh Choi, Bresalier, Robert S., Raz, Avraham
Publicado em 2004

Assuntos: “...Cell Growth and Development...”
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GDP-Mannose Pyrophosphorylase: A Biologically Validated Target for Drug Development Against Leishmaniasis

Por Pomel, Sébastien, Mao, Wei, Ha-Duong, Tâp, Cavé, Christian, Loiseau, Philippe M.
Publicado no Front Cell Infect Microbiol (2019)

“... countries around the world. In order to find new antileishmanial drugs, an original approach consists...”
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Opportunities and Challenges for Drug Development: Public–Private Partnerships, Adaptive Designs and Big Data

Por Yildirim, Oktay, Gottwald, Matthias, Schüler, Peter, Michel, Martin C.
Publicado no Front Pharmacol (2016)

“...Drug development faces the double challenge of increasing costs and increasing pressure on pricing...”
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Which Patients Will Benefit from a Switch in Therapy from Premixed Insulin to Insulin Glargine plus Oral Antidiabetic Drugs? Further Analysis of the Lantus Registry Study

Por Bu, Shi, Zhang, Xuelian, Zhu, Haiqing, Shuai, Ying, Xing, Xiaoyan, Yang, Wenying
Publicado no Diabetes Ther (2017)

“... antidiabetic drugs (OADs). METHODS: The modified intention-to-treat population of the Lantus Registry Study...”
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On the attenuation and amplification of molecular noise in genetic regulatory networks

Por Chen, Bor-Sen, Wang, Yu-Chao
Publicado em 2006

“... under extrinsic noises. CONCLUSION: In this study, a stochastic nonlinear dynamic model is developed...”
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The role of noise and positive feedback in the onset of autosomal dominant diseases

Por Bosl, William J, Li, Rong
Publicado em 2010

“..., haploinsufficiency can involve a variety of additional mechanisms, such as noise in gene expression or protein levels...”
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