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Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells

Por Garrett, Wendy S., Punit, Shivesh, Gallini, Carey A., Michaud, Monia, Zhang, Dorothy, Sigrist, Kirsten S., Lord, Graham M., Glickman, Jonathan N., Glimcher, Laurie H.
Publicado em 2009

“...We previously described a mouse model of ulcerative colitis linked to T-bet deficiency...”
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Nod/Ripk2 signaling in dendritic cells activates IL-17A–secreting innate lymphoid cells and drives colitis in T-bet(−/−).Rag2(−/−) (TRUC) mice

Por Ermann, Joerg, Staton, Tracy, Glickman, Jonathan N., de Waal Malefyt, Rene, Glimcher, Laurie H.
Publicado em 2014

“... pathway in this model. Using an in vitro coculture system of bone marrow-derived dendritic cells (DCs...”
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