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1

Targeting the epigenetics of the DNA damage response in breast cancer

Targeting the epigenetics of the DNA damage response in breast cancer

Por Montenegro, M F, González-Guerrero, R, Sánchez-del-Campo, L, Piñero-Madrona, A, Cabezas-Herrera, J, Rodríguez-López, J N
Publicado no Cell Death Dis (2016)

“...Cancer is as much an epigenetic disease as it is a genetic disease, and epigenetic alterations...”
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2

6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27

6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27

Por Yalcin, A, Clem, B F, Imbert-Fernandez, Y, Ozcan, S C, Peker, S, O'Neal, J, Klarer, A C, Clem, A L, Telang, S, Chesney, J
Publicado em 2014

“... their synthesis of fructose-2,6-bisphosphate (F2,6BP), a potent allosteric activator of 6-phosphofructo-1-kinase...”
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3

p16(INK4A) and p14(ARF) Gene Promoter Hypermethylation as Prognostic Biomarker in Oral and Oropharyngeal Squamous Cell Carcinoma: A Review

p16(INK4A) and p14(ARF) Gene Promoter Hypermethylation as Prognostic Biomarker in Oral and Oropharyngeal Squamous Cell Carcinoma: A Review

Por Al-Kaabi, A., van Bockel, L. W., Pothen, A. J., Willems, S. M.
Publicado em 2014

“..., it has become clear that silencing of cancer related genes is not exclusively a result of genetic changes...”
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4

Stereotactic ablative radiotherapy for stage I NSCLC: Recent advances and controversies

Stereotactic ablative radiotherapy for stage I NSCLC: Recent advances and controversies

Por Senan, Suresh, Palma, David A., Lagerwaard, Frank J.
Publicado em 2011

“...Stereotactic ablative radiotherapy (SABR) is a technique that has rapidly entered routine care...”
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5

Integrin Involvement in Freeze Resistance of Androgen-Insensitive Prostate Cancer

Integrin Involvement in Freeze Resistance of Androgen-Insensitive Prostate Cancer

Por Baust, John G., Klossner, Daniel P., VanBuskirk, Robert G., Gage, Andrew A., Mouraviev, Vladimir, Polascik, Thomas J., Baust, John M.
Publicado em 2010

“...Cryoablation has emerged as a primary therapy to treat prostate cancer. While effective...”
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6

CD95 maintains stem cell-like and non-classical EMT programs in primary human glioblastoma cells

CD95 maintains stem cell-like and non-classical EMT programs in primary human glioblastoma cells

Por Drachsler, M, Kleber, S, Mateos, A, Volk, K, Mohr, N, Chen, S, Cirovic, B, Tüttenberg, J, Gieffers, C, Sykora, J, Wirtz, C R, Mueller, W, Synowitz, M, Martin-Villalba, A
Publicado no Cell Death Dis (2016)

“...Glioblastoma (GBM) is one of the most aggressive types of cancer with limited therapeutic options...”
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7

USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis

USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis

Por Fan, Y-H, Cheng, J, Vasudevan, S A, Dou, J, Zhang, H, Patel, R H, Ma, I T, Rojas, Y, Zhao, Y, Yu, Y, Zhang, H, Shohet, J M, Nuchtern, J G, Kim, E S, Yang, J
Publicado em 2013

“...Neuroblastoma (NB) is a common pediatric cancer and contributes to more than 15% of all pediatric...”
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8

Far upstream element-binding protein 1 is a prognostic biomarker and promotes nasopharyngeal carcinoma progression

Far upstream element-binding protein 1 is a prognostic biomarker and promotes nasopharyngeal carcinoma progression

Por Liu, Z-H, Hu, J-L, Liang, J-Z, Zhou, A-J, Li, M-Z, Yan, S-M, Zhang, X, Gao, S, Chen, L, Zhong, Q, Zeng, M-S
Publicado no Cell Death Dis (2015)

“... progression. Our results suggest that FBP1 can not only serve as a useful prognostic biomarker for NPC...”
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9

miRNA-205 targets VEGFA and FGF2 and regulates resistance to chemotherapeutics in breast cancer

miRNA-205 targets VEGFA and FGF2 and regulates resistance to chemotherapeutics in breast cancer

Por Hu, Y, Qiu, Y, Yagüe, E, Ji, W, Liu, J, Zhang, J
Publicado no Cell Death Dis (2016)

“... may serve as a predictive biomarker and a potential therapeutic target in breast cancer treatment....”
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10

Depletion of intermediate filament protein Nestin, a target of microRNA-940, suppresses tumorigenesis by inducing spontaneous DNA damage accumulation in human nasopharyngeal carcinoma

Depletion of intermediate filament protein Nestin, a target of microRNA-940, suppresses...

Por Ma, J, Sun, F, Li, C, Zhang, Y, Xiao, W, Li, Z, Pan, Q, Zeng, H, Xiao, G, Yao, K, Hong, A, An, J
Publicado no Cell Death Dis (2014)

“... the proliferation of a variety of cancer cell lines, arrests cells cycle, induces caspase-3/7-dependent apoptosis...”
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11

Chemotherapy diminishes lipid storage capacity of adipose tissue in a preclinical model of colon cancer

Chemotherapy diminishes lipid storage capacity of adipose tissue in a preclinical model of colon cancer

Por Ebadi, Maryam, Field, Catherine J., Lehner, Richard, Mazurak, Vera C.
Publicado no Lipids Health Dis (2017)

“... tissue was isolated. Healthy rats served as a reference group. Histological analysis (hematoxylin...”
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12

ARHGAP10, downregulated in ovarian cancer, suppresses tumorigenicity of ovarian cancer cells

ARHGAP10, downregulated in ovarian cancer, suppresses tumorigenicity of ovarian cancer cells

Por Luo, N, Guo, J, Chen, L, Yang, W, Qu, X, Cheng, Z
Publicado no Cell Death Dis (2016)

“... of ovarian cancer. ARHGAP10 is a member of RhoGAP proteins and inactivates Cdc42 by converting GTP-bound form...”
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13

Hooking the big one: the potential of zebrafish xenotransplantation to reform cancer drug screening in the genomic era

Hooking the big one: the potential of zebrafish xenotransplantation to reform cancer drug screening in the genomic era

Por Veinotte, Chansey J., Dellaire, Graham, Berman, Jason N.
Publicado em 2014

“... libraries. Xenotransplantation of human cancer cells into zebrafish embryos builds on this work and enables...”
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14

Breast Cancer Stage, Surgery, and Survival Statistics for Idaho’s National Breast and Cervical Cancer Early Detection Program Population, 2004–2012

Breast Cancer Stage, Surgery, and Survival Statistics for Idaho’s National Breast and Cervical Cancer Early Detection Program Population, 2004–2012

Por Johnson, Christopher J., Graff, Robert, Moran, Patti, Cariou, Charlene, Bordeaux, Susan
Publicado no Prev Chronic Dis (2015)

“..., cause-specific breast cancer survival proportions diverged over time, with a 5.1 percentage-point...”
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15

BIS targeting induces cellular senescence through the regulation of 14-3-3 zeta/STAT3/SKP2/p27 in glioblastoma cells

BIS targeting induces cellular senescence through the regulation of 14-3-3 zeta/STAT3/SKP2/p27 in glioblastoma cells

Por Lee, J-J, Lee, J-S, Cui, M N, Yun, H H, Kim, H Y, Lee, S H, Lee, J-H
Publicado no Cell Death Dis (2014)

“..., our findings suggest that a downregulation of BIS expression could serve as a potential strategy...”
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16

The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular cells

The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular cells

Por Cheng, P, Ni, Z, Dai, X, Wang, B, Ding, W, Rae Smith, A, Xu, L, Wu, D, He, F, Lian, J
Publicado em 2013

“... in HCC cells, partly due to ROS generation, suggesting that antioxidant may serve as a potential...”
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17

Revised Definitions of Invasive Fungal Disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group

Revised Definitions of Invasive Fungal Disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy...

Por De Pauw, Ben, Walsh, Thomas J., Donnelly, J. Peter, Stevens, David A., Edwards, John E., Calandra, Thierry, Pappas, Peter G., Maertens, Johan, Lortholary, Olivier, Kauffman, Carol A., Denning, David W., Patterson, Thomas F., Maschmeyer, Georg, Bille, Jacques, Dismukes, William E., Herbrecht, Raoul, Hope, William W., Kibbler, Christopher C., Kullberg, Bart Jan, Marr, Kieren A., Muñoz, Patricia, Odds, Frank C., Perfect, John R., Restrepo, Angela, Ruhnke, Markus, Segal, Brahm H., Sobel, Jack D., Sorrell, Tania C., Viscoli, Claudio, Wingard, John R., Zaoutis, Theoklis, Bennett, John E.
Publicado em 2008

“... disease are intended to advance clinical and epidemiological research and may serve as a useful model...”
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18

ASCCP Colposcopy Standards: How do we perform colposcopy? Implications for establishing standards

ASCCP Colposcopy Standards: How do we perform colposcopy? Implications for establishing standards

Por Waxman, Alan G., Conageski, Christine, Silver, Michelle I., Tedeschi, Candace, Stier, Elizabeth A., Apgar, Barbara, Huh, Warner K., Wentzensen, Nicolas, Massad, L. Stewart, Khan, Michelle J., Mayeaux, Edward J., Einstein, Mark H., Schiffman, Mark H., Guido, Richard S.
Publicado no J Low Genit Tract Dis (2017)

“...-procedure follow-up. CONCLUSIONS: These guidelines are intended to serve as a guide to standardize...”
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19

The Costs of an Outreach Intervention for Low-Income Women With Abnormal Pap Smears

The Costs of an Outreach Intervention for Low-Income Women With Abnormal Pap Smears

Por Wagner, Todd H, Engelstad, Linda P, McPhee, Stephen J, Pasick, Rena J
Publicado em 2006

“... in public hospitals that serve women at increased risk for cervical cancer. This randomized controlled trial...”
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20

Inducement of mitosis delay by cucurbitacin E, a novel tetracyclic triterpene from climbing stem of Cucumis melo L., through GADD45γ in human brain malignant glioma (GBM) 8401 cells

Inducement of mitosis delay by cucurbitacin E, a novel tetracyclic triterpene from climbing stem...

Por Hsu, Y-C, Chen, M-J, Huang, T-Y
Publicado em 2014

“... and antitumor activities as well as a potent chemo-preventive action against cancer. The present study...”
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