Maternal diet, aging and diabetes meet at a chromatin loop

Por Ozanne, Susan E., Sandovici, Ionel, Constância, Miguel
Publicado em 2011

Tandem Repeat Hypothesis in Imprinting: Deletion of a Conserved Direct Repeat Element Upstream of H19 Has No Effect on Imprinting in the Igf2-H19 Region

Por Lewis, Annabelle, Mitsuya, Kohzoh, Constancia, Miguel, Reik, Wolf
Publicado em 2004

Intergenerational epigenetic inheritance in models of developmental programming of adult disease

Por Fernandez-Twinn, Denise S., Constância, Miguel, Ozanne, Susan E.
Publicado no Semin Cell Dev Biol (2015)

Biomarkers of Aging: From Cellular Senescence to Age-Associated Diseases

Por Martins, Maria João, Constância, Miguel, Neves, Delminda, Simm, Andreas
Publicado no Oxid Med Cell Longev (2017)

Placental phenotype and the insulin‐like growth factors: resource allocation to fetal growth

Por Sferruzzi‐Perri, Amanda N., Sandovici, Ionel, Constancia, Miguel, Fowden, Abigail L.
Publicado no J Physiol (2017)

Maternal and fetal genomes interplay through phosphoinositol 3-kinase(PI3K)-p110α signaling to modify placental resource allocation

Por Sferruzzi-Perri, Amanda N., López-Tello, Jorge, Fowden, Abigail L., Constancia, Miguel
Publicado no Proc Natl Acad Sci U S A (2016)

An intragenic methylated region in the imprinted Igf2 gene augments transcription

Por Murrell, Adele, Heeson, Sarah, Bowden, Lucy, Constância, Miguel, Dean, Wendy, Kelsey, Gavin, Reik, Wolf
Publicado em 2001

Regulation of supply and demand for maternal nutrients in mammals by imprinted genes

Por Reik, Wolf, Constância, Miguel, Fowden, Abigail, Anderson, Neil, Dean, Wendy, Ferguson-Smith, Anne, Tycko, Benjamin, Sibley, Colin
Publicado em 2003

An upstream repressor element plays a role in Igf2 imprinting

Por Eden, Sharon, Constancia, Miguel, Hashimshony, Tamar, Dean, Wendy, Goldstein, Beth, Johnson, Alfred C., Keshet, Ilana, Reik, Wolf, Cedar, Howard
Publicado em 2001

Raised Late Pregnancy Glucose Concentrations in Mice Carrying Pups With Targeted Disruption of H19(Δ13)

Por Petry, Clive J., Evans, Mark L., Wingate, Dianne L., Ong, Ken K., Reik, Wolf, Constância, Miguel, Dunger, David B.
Publicado em 2010

Increased Placental Glucose Transport Rates in Pregnant Mice Carrying Fetuses with Targeted Disruption of Their Placental-Specific Igf2 Transcripts Are Not Associated with Raised C...

Por Petry, Clive J., Evans, Mark L., Wingate, Dianne L., Ong, Ken K., Reik, Wolf, Constância, Miguel, Dunger, David B.
Publicado em 2011

Genome-wide oxidative bisulfite sequencing identifies sex-specific methylation differences in the human placenta

Por Gong, Sungsam, Johnson, Michelle D, Dopierala, Justyna, Gaccioli, Francesca, Sovio, Ulla, Constância, Miguel, Smith, Gordon CS, Charnock-Jones, D Stephen
Publicado no Epigenetics (2018)

Extracardiac control of embryonic cardiomyocyte proliferation and ventricular wall expansion

Por Shen, Hua, Cavallero, Susana, Estrada, Kristine D., Sandovici, Ionel, Kumar, S. Ram, Makita, Takako, Lien, Ching-Ling, Constancia, Miguel, Sucov, Henry M.
Publicado no Cardiovasc Res (2015)

Igf2 pathway dependency of the Trp53 developmental and tumour phenotypes

Por Haley, Victoria L, Barnes, David J, Sandovici, Ionel, Constancia, Miguel, Graham, Christopher F, Pezzella, Francesco, Bühnemann, Claudia, Carter, Emma J, Hassan, A Bassim
Publicado em 2012

Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems

Por Constância, Miguel, Angiolini, Emily, Sandovici, Ionel, Smith, Paul, Smith, Rachel, Kelsey, Gavin, Dean, Wendy, Ferguson-Smith, Anne, Sibley, Colin P., Reik, Wolf, Fowden, Abigail
Publicado em 2005

Ageing is associated with molecular signatures of inflammation and type 2 diabetes in rat pancreatic islets

Por Sandovici, Ionel, Hammerle, Constanze M., Cooper, Wendy N., Smith, Noel H., Tarry-Adkins, Jane L., Dunmore, Benjamin J., Bauer, Julien, Andrews, Simon R., Yeo, Giles S. H., Ozanne, Susan E., Constância, Miguel
Publicado no Diabetologia (2015)

Placental polyamine metabolism differs by fetal sex, fetal growth restriction, and preeclampsia

Por Gong, Sungsam, Sovio, Ulla, Aye, Irving L.M.H., Gaccioli, Francesca, Dopierala, Justyna, Johnson, Michelle D., Wood, Angela M., Cook, Emma, Jenkins, Benjamin J., Koulman, Albert, Casero, Robert A., Constância, Miguel, Charnock-Jones, D. Stephen, Smith, Gordon C.S.
Publicado no JCI Insight (2018)

Maternal diet and aging alter the epigenetic control of a promoter–enhancer interaction at the Hnf4a gene in rat pancreatic islets

Por Sandovici, Ionel, Smith, Noel H., Nitert, Marloes Dekker, Ackers-Johnson, Matthew, Uribe-Lewis, Santiago, Ito, Yoko, Jones, R. Huw, Marquez, Victor E., Cairns, William, Tadayyon, Mohammed, O’Neill, Laura P., Murrell, Adele, Ling, Charlotte, Constância, Miguel, Ozanne, Susan E.
Publicado em 2011

Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesity triggered by chronic exposure to p,p’-DDE

Por Pestana, Diogo, Teixeira, Diana, Meireles, Manuela, Marques, Cláudia, Norberto, Sónia, Sá, Carla, Fernandes, Virgínia C., Correia-Sá, Luísa, Faria, Ana, Guardão, Luísa, Guimarães, João T., Cooper, Wendy N., Sandovici, Ionel, Domingues, Valentina F., Delerue-Matos, Cristina, Monteiro, Rosário, Constância, Miguel, Calhau, Conceição
Publicado no Sci Rep (2017)