Pitavastatin-attenuated cardiac dysfunction in mice with dilated cardiomyopathy via regulation of myocardial calcium handling proteins

Por Hu Wei, Jiang Wen-Bing
Publicado em 2014-03-01

Comparative bioavailability of two oral formulations of clopidogrel: Determination of clopidogrel and its carboxylic acid metabolite (SR26334) under fasting and fed conditions in h...

Por Brvar Nina, Lachance Sylvain, Lévesque Ann, Breznik Marjanca, Cvitkovič Marčič Lea, Merslavič Mateja, Grabnar Iztok, Mateovič-Rojnik Tatjana
Publicado em 2014-03-01

Effect of selected catechins on doxorubicin antiproliferative efficacy and hepatotoxicity in vitro

Por Rudolfová Petra, Hanušová Veronika, Skálová Lenka, Bártíková Hana, Matoušková Petra, Boušová Iva
Publicado em 2014-06-01

Development of small molecule extracellular signal-regulated kinases (ERKs) inhibitors for cancer therapy

Por Xiaoli Pan, Junping Pei, Aoxue Wang, Wen Shuai, Lu Feng, Faqian Bu, Yumeng Zhu, Lan Zhang, Guan Wang, Liang Ouyang
Publicado em 2022-05-01

Bile acid coordinates microbiota homeostasis and systemic immunometabolism in cardiometabolic diseases

Por Baoyi Guan, Jinlin Tong, Haiping Hao, Zhixu Yang, Keji Chen, Hao Xu, Anlu Wang
Publicado em 2022-05-01

Structure‒tissue exposure/selectivity relationship (STR) correlates with clinical efficacy/safety

Por Wei Gao, Hongxiang Hu, Lipeng Dai, Miao He, Hebao Yuan, Huixia Zhang, Jinhui Liao, Bo Wen, Yan Li, Maria Palmisano, Mohamed Dit Mady Traore, Simon Zhou, Duxin Sun
Publicado em 2022-05-01

Cover Story

Publicado em 2022-05-01

Emerging vaccine nanotechnology: From defense against infection to sniping cancer

Por Chan Feng, Yongjiang Li, Bijan Emiliano Ferdows, Dylan Neal Patel, Jiang Ouyang, Zhongmin Tang, Na Kong, Enguo Chen, Wei Tao
Publicado em 2022-05-01

Drug discovery of sclerostin inhibitors

Por Sifan Yu, Dijie Li, Ning Zhang, Shuaijian Ni, Meiheng Sun, Luyao Wang, Huan Xiao, Dingdong Liu, Jin Liu, Yuanyuan Yu, Zongkang Zhang, Samuel Tin Yui Yeung, Shu Zhang, Aiping Lu, Zhenlin Zhang, Baoting Zhang, Ge Zhang
Publicado em 2022-05-01

Discovery of ARF1-targeting inhibitor demethylzeylasteral as a potential agent against breast cancer

Por Jie Chang, Ruirui Yang, Lifan Chen, Zisheng Fan, Jingyi Zhou, Hao Guo, Yinghui Zhang, Yadan Liu, Guizhen Zhou, Keke Zhang, Kaixian Chen, Hualiang Jiang, Mingyue Zheng, Sulin Zhang
Publicado em 2022-05-01

Tetrahedral DNA nanostructures synergize with MnO2 to enhance antitumor immunity via promoting STING activation and M1 polarization

Por Siping Liang, Jiaying Li, Zhengyu Zou, Miao Mao, Siqi Ming, Fan Lin, Ziyan Zhang, Can Cao, Jinyu Zhou, Yuanqing Zhang, Jiaping Li, Minhao Wu
Publicado em 2022-05-01

Inhibition of intracellular proton-sensitive Ca2+-permeable TRPV3 channels protects against ischemic brain injury

Por Xiaoling Chen, Jingliang Zhang, KeWei Wang
Publicado em 2022-05-01

Detailed resume of RNA m6A demethylases

Por Dandan Shen, Bo Wang, Ya Gao, Lijuan Zhao, Yaping Bi, Jinge Zhang, Ning Wang, Huiqin Kang, Jingru Pang, Ying Liu, Luping Pang, Zhe-Sheng Chen, Yi-Chao Zheng, Hong-Min Liu
Publicado em 2022-05-01

Self-assembling, pH-responsive nanoflowers for inhibiting PAD4 and neutrophil extracellular trap formation and improving the tumor immune microenvironment

Por Di Zhu, Yu Lu, Lin Gui, Wenjing Wang, Xi Hu, Su Chen, Yanming Wang, Yuji Wang
Publicado em 2022-05-01

Enhancing cancer chemo-immunotherapy by biomimetic nanogel with tumor targeting capacity and rapid drug-releasing in tumor microenvironment

Por Lihuan Shang, Xue Jiang, Ting Yang, Hongbo Xu, Qi Xie, Mei Hu, Conglian Yang, Li Kong, Zhiping Zhang
Publicado em 2022-05-01

Intravenous route to choroidal neovascularization by macrophage-disguised nanocarriers for mTOR modulation

Por Weiyi Xia, Chao Li, Qinjun Chen, Jiancheng Huang, Zhenhao Zhao, Peixin Liu, Kai Xu, Lei Li, Fangyuan Hu, Shujie Zhang, Tao Sun, Chen Jiang, Chen Zhao
Publicado em 2022-05-01

The long-circulating effect of pegylated nanoparticles revisited via simultaneous monitoring of both the drug payloads and nanocarriers

Por Wufa Fan, Haixia Peng, Zhou Yu, Luting Wang, Haisheng He, Yuhua Ma, Jianping Qi, Yi Lu, Wei Wu
Publicado em 2022-05-01

Aristolochic acids exposure was not the main cause of liver tumorigenesis in adulthood

Por Shuzhen Chen, Yaping Dong, Xinming Qi, Qiqi Cao, Tao Luo, Zhaofang Bai, Huisi He, Zhecai Fan, Lingyan Xu, Guozhen Xing, Chunyu Wang, Zhichao Jin, Zhixuan Li, Lei Chen, Yishan Zhong, Jiao Wang, Jia Ge, Xiaohe Xiao, Xiuwu Bian, Wen Wen, Jin Ren, Hongyang Wang
Publicado em 2022-05-01

Stimuli-responsive nano vehicle enhances cancer immunotherapy by coordinating mitochondria-targeted immunogenic cell death and PD-L1 blockade

Por Qiuyi Li, Cheng Chen, Jinxia Kong, Lian Li, Junlin Li, Yuan Huang
Publicado em 2022-05-01

Self-assembling protein nanocarrier for selective delivery of cytotoxic polypeptides to CXCR4+ head and neck squamous cell carcinoma tumors

Por Elisa Rioja-Blanco, Irene Arroyo-Solera, Patricia Álamo, Isolda Casanova, Alberto Gallardo, Ugutz Unzueta, Naroa Serna, Laura Sánchez-García, Miquel Quer, Antonio Villaverde, Esther Vázquez, Ramon Mangues, Lorena Alba-Castellón, Xavier León
Publicado em 2022-05-01