Self-assembling, pH-responsive nanoflowers for inhibiting PAD4 and neutrophil extracellular trap formation and improving the tumor immune microenvironment

Self-assembling carrier-free nanodrugs are attractive agents because they accumulate at tumor by an enhanced permeability and retention (EPR) effect without introduction of inactive substances, and some nanodrugs can alter the immune environment. We synthesized a peptidyl arginine deiminase 4 (PAD4)...

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Detalhes bibliográficos
Main Authors: Di Zhu, Yu Lu, Lin Gui, Wenjing Wang, Xi Hu, Su Chen, Yanming Wang, Yuji Wang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2022-05-01
Colecção:Acta Pharmaceutica Sinica B
Assuntos:
pH-Response
Self-assembly
Carrier-free
Nanoflowers
Neutrophil extracellular traps
Single-cell mass cytometry
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2211383521004391
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