Metabolic flux analysis of 3D spheroids reveals significant differences in glucose metabolism from matched 2D cultures of colorectal cancer and pancreatic ductal adenocarcinoma cel...

Por Tia R. Tidwell, Gro V. Røsland, Karl Johan Tronstad, Kjetil Søreide, Hanne R. Hagland
Publicado em 2022-05-01

An iron chelation-based combinatorial anticancer therapy comprising deferoxamine and a lactate excretion inhibitor inhibits the proliferation of cancer cells

Por Koichi Fujisawa, Taro Takami, Toshihiko Matsumoto, Naoki Yamamoto, Takahiro Yamasaki, Isao Sakaida
Publicado em 2022-05-01

Common biochemical properties of metabolic genes recurrently dysregulated in tumors

Por Krishnadev Oruganty, Scott Edward Campit, Sainath Mamde, Costas A. Lyssiotis, Sriram Chandrasekaran
Publicado em 2020-05-01

PHGDH supports liver ceramide synthesis and sustains lipid homeostasis

Por Yun Pyo Kang, Aimee Falzone, Min Liu, Paloma González-Sánchez, Bo-Hyun Choi, Jonathan L. Coloff, James J. Saller, Florian A. Karreth, Gina M. DeNicola
Publicado em 2020-06-01

Molecular features that predict the response to antimetabolite chemotherapies

Por Mahya Mehrmohamadi, Seong Ho Jeong, Jason W. Locasale
Publicado em 2017-10-01

Disruption of hypoxia-inducible fatty acid binding protein 7 induces beige fat-like differentiation and thermogenesis in breast cancer cells

Por Masahiro Kawashima, Karim Bensaad, Christos E. Zois, Alessandro Barberis, Esther Bridges, Simon Wigfield, Christoffer Lagerholm, Ruslan I. Dmitriev, Mariko Tokiwa, Masakazu Toi, Dmitri B. Papkovsky, Francesca M. Buffa, Adrian L. Harris
Publicado em 2020-07-01

Exercise inhibits tumor growth and central carbon metabolism in patient-derived xenograft models of colorectal cancer

Por Min Lu, Sydney M Sanderson, Amelia Zessin, Kathleen A Ashcraft, Lee W Jones, Mark W Dewhirst, Jason W Locasale, David S Hsu
Publicado em 2018-11-01

Human mitochondrial MTHFD2 is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase

Por Minhye Shin, Jessica Momb, Dean R. Appling
Publicado em 2017-12-01

Isocitrate dehydrogenase 1-mutated cancers are sensitive to the green tea polyphenol epigallocatechin-3-gallate

Por Tom H. Peeters, Krissie Lenting, Vincent Breukels, Sanne A. M. van Lith, Corina N. A. M. van den Heuvel, Remco Molenaar, Arno van Rooij, Ron Wevers, Paul N. Span, Arend Heerschap, William P. J. Leenders
Publicado em 2019-05-01

Metabolic plasticity imparts erlotinib-resistance in pancreatic cancer by upregulating glucose-6-phosphate dehydrogenase

Por Neha Sharma, Alok Bhushan, Jun He, Gagan Kaushal, Vikas Bhardwaj
Publicado em 2020-09-01

Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancer

Por Kaylyn D. Tousignant, Anja Rockstroh, Berwyck L. J. Poad, Ali Talebi, Reuben S. E. Young, Atefeh Taherian Fard, Rajesh Gupta, Tuo Zang, Chenwei Wang, Melanie L. Lehman, Johan V. Swinnen, Stephen J. Blanksby, Colleen C. Nelson, Martin C. Sadowski
Publicado em 2020-06-01

Body mass index-associated molecular characteristics involved in tumor immune and metabolic pathways

Por Chao Hu, Xiong Chen, Chengyun Yao, Yu Liu, Haojun Xu, Guoren Zhou, Hongping Xia, Jinglin Xia
Publicado em 2020-09-01

Modulating pyrimidine ribonucleotide levels for the treatment of cancer

Por Tanzina Mollick, Sonia Laín
Publicado em 2020-10-01