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PHGDH supports liver ceramide synthesis and sustains lipid homeostasis
Abstract Background d-3-phosphoglycerate dehydrogenase (PHGDH), which encodes the first enzyme in serine biosynthesis, is overexpressed in human cancers and has been proposed as a drug target. However, whether PHGDH is critical for the proliferation or homeostasis of tissues following the postnatal...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMC
2020-06-01
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| Colecção: | Cancer & Metabolism |
| Assuntos: | |
| Acesso em linha: | http://link.springer.com/article/10.1186/s40170-020-00212-x |
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