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Efficient Synthesis of Peptides with 4-Methylpiperidine as Fmoc Removal Reagent by Solid Phase Synthesis

Solid phase peptide synthesis using the Fmoc/ t -Bu strategy (SPPS-Fmoc/tBu) is the most widely used methodology for obtaining synthetic peptides. In this paper, we evaluate the viability of using 4-methylpiperidine as a reagent for deprotection of the amino acid alpha amino group in SPPS-Fmoc/tBu....

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Bibliographic Details
Published in:Journal of the Mexican Chemical Society
Main Authors: Cristian Francisco Vergel Galeano, Zuly Jenny Rivera Monroy, Jaiver Eduardo Rosas Pérez, Javier Eduardo García Castañeda
Format: Artigo
Language:Inglês
Published: Sociedad Química de México 2014
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Online Access:https://www.redalyc.org/articulo.oa?id=47535733004
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