Toxicological Evaluation of Anti-Scrapie Trimethoxychalcones and Oxadiazoles

An altered form of the cellular prion protein, the PrPSc or PrPRes, is implicated in the occurrence of the still untreatable transmissible spongiform encephalopathies. We have previously synthesized and characterized aromatic compounds that inhibit protease-resistant prion protein (PrPRes) accumulat...

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Détails bibliographiques
Publié dans:Anais da Academia Brasileira de Ciências
Auteurs principaux: Claudia P. Figueiredo, Natalia C. Ferreira, Giselle F. Passos, Robson da Costa, Fernanda S. Neves, Clarice S.C. Machado, Alessandra Mascarello, Louise D. Chiaradia-Delatorre, Patrícia D. Neuenfeldt, Ricardo J. Nunes, Yraima Cordeiro
Format: Artigo
Langue:Inglês
Publié: Academia Brasileira de Ciências 2015
Sujets:
Multidisciplinaria (Ciencias Naturales y Exactas)
prion
scrapie
drug safety
acute toxicity
organic compound
Accès en ligne:https://www.redalyc.org/articulo.oa?id=32742178013
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