Loss of mRor1 Enhances the Heart and Skeletal Abnormalities in mRor2-Deficient Mice: Redundant and Pleiotropic Functions of mRor1 and mRor2 Receptor Tyrosine Kinases

The mammalian Ror family of receptor tyrosine kinases consists of two structurally related proteins, Ror1 and Ror2. We have shown that mRor2-deficient mice exhibit widespread skeletal abnormalities, ventricular septal defects in the heart, and respiratory dysfunction, leading to neonatal lethality (...

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Bibliographische Detailangaben
Hauptverfasser: Nomi, Masashi, Oishi, Isao, Kani, Shuichi, Suzuki, Hiroaki, Matsuda, Takeru, Yoda, Akinori, Kitamura, Makiko, Itoh, Kyoko, Takeuchi, Shigeto, Takeda, Kiyoshi, Akira, Shizuo, Ikeya, Makoto, Takada, Shinji, Minami, Yasuhiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2001
Schlagworte:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC99997/
https://ncbi.nlm.nih.gov/pubmed/11713269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.24.8329-8335.2001
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