Restoration of Nucleotide Excision Repair in a Helicase-Deficient XPD Mutant from Intragenic Suppression by a Trichothiodystrophy Mutation

The UV-sensitive V-H1 cell line has a T46I substitution mutation in the Walker A box in both alleles of XPD and lacks DNA helicase activity. We characterized three partial revertants that curiously display intermediate UV cytotoxicity (2- to 2.5-fold) but normal levels of UV-induced hprt mutations....

詳細記述

書誌詳細

出版年:	Mol Cell Biol
主要な著者:	George, James W., Salazar, Edmund P., Vreeswijk, Maaike P. G., Lamerdin, Jane E., Reardon, Joyce T., Zdzienicka, Malgorzata Z., Sancar, Aziz, Kadkhodayan, Saloumeh, Tebbs, Robert S., Mullenders, Leon H. F., Thompson, Larry H.
フォーマット:	Artigo
言語:	Inglês
出版事項:	Taylor & Francis 2001
主題:	DNA Dynamics and Chromosome Structure
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC99909/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11585917/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.21.7355-7365.2001
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