Restoration of Nucleotide Excision Repair in a Helicase-Deficient XPD Mutant from Intragenic Suppression by a Trichothiodystrophy Mutation

The UV-sensitive V-H1 cell line has a T46I substitution mutation in the Walker A box in both alleles of XPD and lacks DNA helicase activity. We characterized three partial revertants that curiously display intermediate UV cytotoxicity (2- to 2.5-fold) but normal levels of UV-induced hprt mutations....

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: George, James W., Salazar, Edmund P., Vreeswijk, Maaike P. G., Lamerdin, Jane E., Reardon, Joyce T., Zdzienicka, Malgorzata Z., Sancar, Aziz, Kadkhodayan, Saloumeh, Tebbs, Robert S., Mullenders, Leon H. F., Thompson, Larry H.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2001
Предметы:
DNA Dynamics and Chromosome Structure
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC99909/
https://ncbi.nlm.nih.gov/pubmed/11585917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.21.7355-7365.2001
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы