RhoB Is Dispensable for Mouse Development, but It Modifies Susceptibility to Tumor Formation as Well as Cell Adhesion and Growth Factor Signaling in Transformed Cells

RhoB is an endosomal small GTPase that is implicated in the response to growth factors, genotoxic stress, and farnesyltransferase inhibitors. To gain insight into its physiological functions we examined the consequences of homozygous gene deletion in the mouse. Loss of RhoB did not adversely affect...

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Opis bibliograficzny
Główni autorzy: Liu, Ai-Xue, Rane, Neena, Liu, Jeh-Ping, Prendergast, George C.
Format: Artigo
Język:Inglês
Wydane: American Society for Microbiology 2001
Hasła przedmiotowe:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC99867/
https://ncbi.nlm.nih.gov/pubmed/11564874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.20.6906-6912.2001
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