RhoB Is Dispensable for Mouse Development, but It Modifies Susceptibility to Tumor Formation as Well as Cell Adhesion and Growth Factor Signaling in Transformed Cells

RhoB is an endosomal small GTPase that is implicated in the response to growth factors, genotoxic stress, and farnesyltransferase inhibitors. To gain insight into its physiological functions we examined the consequences of homozygous gene deletion in the mouse. Loss of RhoB did not adversely affect...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Liu, Ai-Xue, Rane, Neena, Liu, Jeh-Ping, Prendergast, George C.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2001
Assuntos:	Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC99867/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11564874/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.20.6906-6912.2001
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