Twofold Reduction of Phosphofructokinase Activity in Lactococcus lactis Results in Strong Decreases in Growth Rate and in Glycolytic Flux

Two mutant strains of Lactococcus lactis in which the promoter of the las operon, harboring pfk, pyk, and ldh, were replaced by synthetic promoters were constructed. These las mutants had an approximately twofold decrease in the activity of phosphofructokinase, whereas the activities of pyruvate kin...

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Bibliographic Details
Main Authors: Andersen, Heidi W., Solem, Christian, Hammer, Karin, Jensen, Peter R.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Physiology and Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC99644/
https://ncbi.nlm.nih.gov/pubmed/11344154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.183.11.3458-3467.2001
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