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Role of Adaptor Complex AP-3 in Targeting Wild-Type and Mutated CD63 to Lysosomes

CD63 is a lysosomal membrane protein that belongs to the tetraspanin family. Its carboxyterminal cytoplasmic tail sequence contains the lysosomal targeting motif GYEVM. Strong, tyrosine-dependent interaction of the wild-type carboxyterminal tail of CD63 with the AP-3 adaptor subunit μ3 was observed...

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Published in:Mol Biol Cell
Main Authors: Rous, Brian A., Reaves, Barbara J., Ihrke, Gudrun, Briggs, John A.G., Gray, Sally R., Stephens, David J., Banting, George, Luzio, J. Paul
Format: Artigo
Language:Inglês
Published: American Society for Cell Biology 2002
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Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC99620/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11907283/
https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.01-08-0409
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