Gadd153 Sensitizes Cells to Endoplasmic Reticulum Stress by Down-Regulating Bcl2 and Perturbing the Cellular Redox State

gadd153, also known as chop, is a highly stress-inducible gene that is robustly expressed following disruption of homeostasis in the endoplasmic reticulum (ER) (so-called ER stress). Although all reported types of ER stress induce expression of Gadd153, its role in the stress response has remained l...

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Bibliographic Details
Main Authors: McCullough, Karen D., Martindale, Jennifer L., Klotz, Lars-Oliver, Aw, Tak-Yee, Holbrook, Nikki J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC99578/
https://ncbi.nlm.nih.gov/pubmed/11158311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.4.1249-1259.2001
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