The Chinese Hamster Dihydrofolate Reductase Replication Origin Beta Is Active at Multiple Ectopic Chromosomal Locations and Requires Specific DNA Sequence Elements for Activity

To identify cis-acting genetic elements essential for mammalian chromosomal DNA replication, a 5.8-kb fragment from the Chinese hamster dihydrofolate reductase (DHFR) locus containing the origin beta (ori-β) initiation region was stably transfected into random ectopic chromosomal locations in a hams...

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Detalhes bibliográficos
Main Authors: Altman, Amy L., Fanning, Ellen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC99564/
https://ncbi.nlm.nih.gov/pubmed/11158297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.4.1098-1110.2001
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