DNA Immunization with Trypanosoma cruzi HSP70 Fused to the KMP11 Protein Elicits a Cytotoxic and Humoral Immune Response against the Antigen and Leads to Protection

Murine immunization with Trypanosoma cruzi KMP11-HSP70 fused genes but not the KMP11 gene alone elicited both an immunoglobulin G2a long-lasting humoral immune response against KMP11 protein and activation of CD8(+) cytotoxic T lymphocytes specific for two KMP11 peptides containing A2 motifs. Moreov...

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Bibliografiske detaljer
Main Authors: Planelles, Lourdes, Thomas, M. Carmen, Alonso, Carlos, López, Manuel C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2001
Fag:
Fungal and Parasitic Infections
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC98798/
https://ncbi.nlm.nih.gov/pubmed/11553607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.10.6558-6563.2001
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