Impaired Pulmonary NF-κB Activation in Response to Lipopolysaccharide in NADPH Oxidase-Deficient Mice

Reactive oxygen species (ROS) are thought to be involved in intracellular signaling, including activation of the transcription factor NF-κB. We investigated the role of NADPH oxidase in the NF-κB activation pathway by utilizing knockout mice (p47(phox−/−)) lacking the p47(phox) component of NADPH ox...

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Autori principali: Koay, M. Audrey, Christman, John W., Segal, Brahm H., Venkatakrishnan, Annapurna, Blackwell, Thomas R., Holland, Steven M., Blackwell, Timothy S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2001
Soggetti:
Host Response and Inflammation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC98726/
https://ncbi.nlm.nih.gov/pubmed/11553535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.10.5991-5996.2001
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