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DNA Sequences Encoding CD4(+) and CD8(+) T-Cell Epitopes Are Important for Efficient Protective Immunity Induced by DNA Vaccination with a Trypanosoma cruzi Gene
Immunization of BALB/c mice with a plasmid containing the gene for Trypanosoma cruzi trans-sialidase (TS) induced antibodies that inhibited TS enzymatic activity, CD4(+) Th1 and CD8(+) Tc1 cells, and protective immunity against infection. We used this model to obtain basic information on the require...
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| Główni autorzy: | , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Microbiology
2001
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC98660/ https://ncbi.nlm.nih.gov/pubmed/11500420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.9.5477-5486.2001 |
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