DNA Sequences Encoding CD4(+) and CD8(+) T-Cell Epitopes Are Important for Efficient Protective Immunity Induced by DNA Vaccination with a Trypanosoma cruzi Gene

Immunization of BALB/c mice with a plasmid containing the gene for Trypanosoma cruzi trans-sialidase (TS) induced antibodies that inhibited TS enzymatic activity, CD4(+) Th1 and CD8(+) Tc1 cells, and protective immunity against infection. We used this model to obtain basic information on the require...

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Main Authors: Fujimura, Adriana E., Kinoshita, Sheila S., Pereira-Chioccola, Vera L., Rodrigues, Mauricio M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2001
Assuntos:
Fungal and Parasitic Infections
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC98660/
https://ncbi.nlm.nih.gov/pubmed/11500420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.9.5477-5486.2001
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