Phagocytosis of Wild-Type Legionella pneumophila Occurs through a Wortmannin-Insensitive Pathway

Wild-type Legionella pneumophila grows in human macrophages within a replicative phagosome, avoiding lysosomal fusion, while nonreplicative mutants are killed in lysosomes. Wortmannin, a phosphatidylinositol 3-kinase (PI3K) inhibitor, blocks phagocytosis of an avirulent mutant, but not of wild-type...

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izdano v:	Infect Immun
Principais autores:	Khelef, Nadia, Shuman, Howard A., Maxfield, Frederick R.
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology (ASM) 2001
Teme:	Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC98612/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11447198/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.69.8.5157-5161.2001
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