Phagocytosis of Wild-Type Legionella pneumophila Occurs through a Wortmannin-Insensitive Pathway

Wild-type Legionella pneumophila grows in human macrophages within a replicative phagosome, avoiding lysosomal fusion, while nonreplicative mutants are killed in lysosomes. Wortmannin, a phosphatidylinositol 3-kinase (PI3K) inhibitor, blocks phagocytosis of an avirulent mutant, but not of wild-type...

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Detalhes bibliográficos
Main Authors: Khelef, Nadia, Shuman, Howard A., Maxfield, Frederick R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC98612/
https://ncbi.nlm.nih.gov/pubmed/11447198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.8.5157-5161.2001
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