Cu,Zn Superoxide Dismutase of Mycobacterium tuberculosis Contributes to Survival in Activated Macrophages That Are Generating an Oxidative Burst

Macrophages produce reactive oxygen species and reactive nitrogen species that have potent antimicrobial activity. Resistance to killing by macrophages is critical to the virulence of Mycobacterium tuberculosis. M. tuberculosis has two genes encoding superoxide dismutase proteins, sodA and sodC. Sod...

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Bibliographic Details
Main Authors: Piddington, Debra L., Fang, Ferric C., Laessig, Tracey, Cooper, Andrea M., Orme, Ian M., Buchmeier, Nancy A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC98590/
https://ncbi.nlm.nih.gov/pubmed/11447176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.8.4980-4987.2001
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