Construction, Genotypic and Phenotypic Characterization, and Immunogenicity of Attenuated ΔguaBA Salmonella enterica Serovar Typhi Strain CVD 915

A promising live attenuated typhoid vaccine candidate strain for mucosal immunization was developed by introducing a deletion in the guaBA locus of pathogenic Salmonella enterica serovar Typhi strain Ty2. The resultant ΔguaBA mutant, serovar Typhi CVD 915, has a gene encoding resistance to arsenite...

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Bibliographische Detailangaben
Hauptverfasser: Wang, Jin Yuang, Pasetti, Marcela F., Noriega, Fernando R., Anderson, Richard J., Wasserman, Steven S., Galen, James E., Sztein, Marcelo B., Levine, Myron M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2001
Schlagworte:
Microbial Immunity and Vaccines
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC98559/
https://ncbi.nlm.nih.gov/pubmed/11447145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.8.4734-4741.2001
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